INT120108

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.22
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
nucleus 1
annulus 1
IVD 1
Mmp13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 61 100.00 Very High Very High Very High
anesthesia 3 93.12 High High
agonist 57 89.68 High High
Potency 16 88.24 High High
Pain 2 80.80 Quite High
Chronic low back pain 1 68.32 Quite High
antagonist 11 67.60 Quite High
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neck Pain 1 80.80 Quite High
Intervertebral Disk Degeneration 1 75.00 Quite High
Low Back Pain 1 68.32 Quite High
Osteoarthritis 13 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Cirrhosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2alpha1 mRNA expression at all time points; and decreased Col10alpha1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1beta mRNA expression induced by upright posture for 7 and 9 months.
Transcription (expression) of MMP13 in IVD associated with metalloproteinase
1) Confidence 0.51 Published 2010 Journal J. Pharmacol. Sci. Section Abstract Doc Link 20472983 Disease Relevance 0.22 Pain Relevance 0.20
Loaded (c8-9) and internal-control discs (c6-7 and c10-11) were dissected and annulus and nucleus tissue were separately analyzed by real-time RT-PCR for levels of anabolic (collagen-1A1, collagen-2A1, aggrecan) and catabolic (MMP-3, MMP-13, ADAMTs-4) mRNA.
Spec (analyzed) Transcription (levels) of MMP-13 in nucleus
2) Confidence 0.36 Published 2004 Journal J. Orthop. Res. Section Abstract Doc Link 15475197 Disease Relevance 0 Pain Relevance 0.09
However, the basal MMP activities were decreased significantly by Wy14643 (Figures 4(a) and 4(b)), as well as the basal mRNA levels for MMP-3 and MMP-13 (Table 2).
Transcription (levels) of MMP-13 associated with metalloproteinase
3) Confidence 0.14 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0 Pain Relevance 0.84
Loaded (c8-9) and internal-control discs (c6-7 and c10-11) were dissected and annulus and nucleus tissue were separately analyzed by real-time RT-PCR for levels of anabolic (collagen-1A1, collagen-2A1, aggrecan) and catabolic (MMP-3, MMP-13, ADAMTs-4) mRNA.
Spec (analyzed) Transcription (levels) of MMP-13 in annulus
4) Confidence 0.12 Published 2004 Journal J. Orthop. Res. Section Abstract Doc Link 15475197 Disease Relevance 0 Pain Relevance 0.09
RESULTS: There was a significant increase in collagenase-3 (MMP-13) mRNA levels, a decrease in stromelysin-1 (MMP-3) mRNA levels, and a decrease in tissue inhibitor of metalloproteinase-2, -3, and -4 mRNA levels.
Transcription (levels) of collagenase-3
5) Confidence 0.03 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0

General Comments

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