INT120109

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.28
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Timp2) aging (Timp2) extracellular region (Timp2)
nucleus (Timp2)
Anatomy Link Frequency
internal 2
Timp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 34 100.00 Very High Very High Very High
endometriosis 4 99.56 Very High Very High Very High
Inflammatory mediators 2 98.36 Very High Very High Very High
Inflammatory response 2 87.80 High High
fibrosis 9 77.28 Quite High
Dismenorea 2 75.00 Quite High
Chronic pancreatitis 2 65.08 Quite High
anesthesia 2 52.00 Quite High
Inflammation 4 25.00 Low Low
cytokine 6 24.68 Low Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 4 99.56 Very High Very High Very High
Primary Sclerosing Cholangitis 18 98.88 Very High Very High Very High
INFLAMMATION 6 98.16 Very High Very High Very High
Pancreatic Cancer 1 94.84 High High
Coronary Heart Disease 4 84.60 Quite High
Fibrosis 10 77.28 Quite High
Dysmenorrhea 2 75.00 Quite High
Injury 5 68.24 Quite High
Infarction 31 66.56 Quite High
Pancreatitis 2 65.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, tissue inhibitor of metalloproteinase-2 (TIMP-2) attenuated Ihh-stimulated PSC migration.
Negative_regulation (inhibitor) of TIMP-2 associated with primary sclerosing cholangitis and metalloproteinase
1) Confidence 0.33 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.94 Pain Relevance 0.31
In addition, tissue inhibitor of metalloproteinase-2 (TIMP-2) attenuated Ihh-stimulated PSC migration.
Negative_regulation (inhibitor) of metalloproteinase-2 associated with primary sclerosing cholangitis and metalloproteinase
2) Confidence 0.29 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.94 Pain Relevance 0.31
OBJECTIVE: To investigate the expressions of matrix metalloproteinase -2, -3 (MMP-2,-3) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in internal uterine endometriosis tissue and endometrium from women with and without endometriosis throughout the menstrual cycle.
Negative_regulation (inhibitor) of TIMP-2 in internal associated with endometriosis and metalloproteinase
3) Confidence 0.17 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 16468658 Disease Relevance 0.27 Pain Relevance 0.35
OBJECTIVE: To investigate the expressions of matrix metalloproteinase -2, -3 (MMP-2,-3) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in internal uterine endometriosis tissue and endometrium from women with and without endometriosis throughout the menstrual cycle.
Negative_regulation (inhibitor) of metalloproteinase-2 in internal associated with endometriosis and metalloproteinase
4) Confidence 0.15 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 16468658 Disease Relevance 0.27 Pain Relevance 0.35
TIMP-2 mediated inhibition of angiogenesis was an MMP-independent mechanism [34].
Negative_regulation (inhibition) of TIMP-2
5) Confidence 0.12 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.16 Pain Relevance 0.08
These are secreted as a pro-enzyme in response to several inflammatory mediators and are inhibited by tissue inhibitor of metalloproteinase-1 (TIMP-1) and tissue inhibitor of metalloproteinase-2 (TIMP-2).
Negative_regulation (inhibitor) of TIMP-2 associated with inflammatory mediators and metalloproteinase
6) Confidence 0.06 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.35 Pain Relevance 0.42
These are secreted as a pro-enzyme in response to several inflammatory mediators and are inhibited by tissue inhibitor of metalloproteinase-1 (TIMP-1) and tissue inhibitor of metalloproteinase-2 (TIMP-2).
Negative_regulation (inhibitor) of metalloproteinase-2 associated with inflammatory mediators and metalloproteinase
7) Confidence 0.06 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.35 Pain Relevance 0.42
Reverse transcription polymerase chain reaction was performed for the collagenases (MMP-1, MMP-8, MMP-13), the stromelysins (MMP-3, MMP-10, MMP-11), and the tissue inhibitors of metalloproteinase (TIMP-1, TIMP-2, TIMP-3, TIMP-4).
Negative_regulation (inhibitors) of TIMP-2
8) Confidence 0.02 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0

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