INT120111

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.65
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
cartilage 1
Mmp13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 61 98.72 Very High Very High Very High
Inflammation 3 96.44 Very High Very High Very High
Pain 35 92.68 High High
Osteoarthritis 33 68.96 Quite High
Angina 2 65.96 Quite High
Mono iodoacetate 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 99.40 Very High Very High Very High
INFLAMMATION 3 96.44 Very High Very High Very High
Atherosclerotic Plaque 12 95.16 Very High Very High Very High
Pain 34 92.68 High High
Disease 3 86.88 High High
Rupture 4 71.72 Quite High
Osteoarthritis 33 68.96 Quite High
Cv General 3 Under Development 2 65.96 Quite High
Myocardial Infarction 2 65.16 Quite High
Acute Coronary Syndrome 2 63.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction in chondropathy scores is likely due to a direct effect of the MMPi on proteinases, such as collagenase 3 or MMP9, that can degrade cartilage matrix proteins.
Spec (likely) Regulation (effect) of collagenase 3 in cartilage
1) Confidence 0.29 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2853084 Disease Relevance 0.73 Pain Relevance 0.63
However, the effect of statin treatment on the serum levels of MMP-13, which has a critical role in the initiation of collagen degradation, is unknown.
Regulation (effect) of MMP-13
2) Confidence 0.07 Published 2008 Journal J Cardiovasc Med (Hagerstown) Section Abstract Doc Link 19001938 Disease Relevance 1.04 Pain Relevance 0.43
On the basis of these previous studies, we discuss the need for studies on the effect of statin treatment on the serum levels of MMP-13 and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels in hypercholesterolemic patients.
Regulation (effect) of MMP-13 associated with metalloproteinase
3) Confidence 0.06 Published 2008 Journal J Cardiovasc Med (Hagerstown) Section Abstract Doc Link 19001938 Disease Relevance 0.88 Pain Relevance 0.41
Western blotting was performed to confirm the mRNA changes demonstrated in collagenase-3 (MMP-13).
Regulation (changes) of collagenase-3
4) Confidence 0.02 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0

General Comments

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