INT120112

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp3) extracellular region (Timp3) cytoplasm (Timp3)
Timp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 9 85.12 High High
Snapping jaw 6 82.40 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 9 99.48 Very High Very High Very High
Temporomandibular Joint Syndrome 6 75.00 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Rotator Cuff Tears 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combination of hypoxia and IL-1beta caused a significant decrease of TIMP-3 compared to hypoxia (P < 0.05).
Negative_regulation (decrease) of TIMP-3 associated with hypoxia
1) Confidence 0.05 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 15598420 Disease Relevance 1.15 Pain Relevance 0.64
Reverse transcription polymerase chain reaction was performed for the collagenases (MMP-1, MMP-8, MMP-13), the stromelysins (MMP-3, MMP-10, MMP-11), and the tissue inhibitors of metalloproteinase (TIMP-1, TIMP-2, TIMP-3, TIMP-4).
Negative_regulation (inhibitors) of TIMP-3
2) Confidence 0.03 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0

General Comments

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