INT120121

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
prefrontal 1
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
addiction 2 98.20 Very High Very High Very High
Opioid 2 94.88 High High
Central nervous system 1 92.20 High High
Endogenous opioid 1 88.56 High High
metalloproteinase 4 50.00 Quite Low
Morphine 1 44.40 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 98.20 Very High Very High Very High
Pain 1 5.00 Very Low Very Low Very Low
Opiate Addiction 1 5.00 Very Low Very Low Very Low
Rotator Cuff Tears 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we have analyzed the activity of two enkephalin-degrading enzymes (puromycin-sensitive aminopeptidase or PSA and aminopeptidase N or APN) and two functionally different, soluble aminopeptidases (aminopeptidase B and aspartyl-aminopeptidase) in postmortem samples of prefrontal cortex and caudate nucleus of eight human heroin addict brains and eight matched-controls.
Spec (analyzed) Transcription (activity) of puromycin-sensitive aminopeptidase in prefrontal associated with enkephalin
1) Confidence 0.23 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 15670637 Disease Relevance 0.10 Pain Relevance 0.46
RESULTS: There was a significant increase in collagenase-3 (MMP-13) mRNA levels, a decrease in stromelysin-1 (MMP-3) mRNA levels, and a decrease in tissue inhibitor of metalloproteinase-2, -3, and -4 mRNA levels.
Transcription (levels) of metalloproteinase
2) Confidence 0.01 Published 2004 Journal Am J Sports Med Section Body Doc Link 15262646 Disease Relevance 0 Pain Relevance 0

General Comments

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