INT120147

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.14
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Tnf) plasma membrane (Tlr4, Tnf) intracellular (Tlr4, Tnf)
cell proliferation (Tnf) extracellular space (Tnf) extracellular region (Tnf)
Anatomy Link Frequency
T lymphocytes 1
Tlr4 (Mus musculus)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 1 97.80 Very High Very High Very High
antagonist 5 92.04 High High
Opioid 3 91.60 High High
cytokine 15 77.88 Quite High
diclofenac 1 75.16 Quite High
opioid receptor 1 74.24 Quite High
cINOD 1 73.08 Quite High
opiate 1 68.36 Quite High
narcan 1 66.92 Quite High
Inflammation 2 54.80 Quite High
Disease Link Frequency Relevance Heat
Toxicity 2 100.00 Very High Very High Very High
Necrosis 6 99.44 Very High Very High Very High
Cancer 4 99.08 Very High Very High Very High
Death 3 98.44 Very High Very High Very High
Shock 2 93.52 High High
Spontaneous Abortion 34 83.56 Quite High
Sepsis 5 76.28 Quite High
Bacterial Infection 1 75.00 Quite High
INFLAMMATION 4 72.84 Quite High
Pressure Volume 2 Under Development 1 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings strongly suggest that LPS exerts its protective action against HD toxicity through the generation of TNF-alpha and may provide better understanding of the mechanism of cytoprotection.
LPS Positive_regulation (generation) of TNF-alpha associated with toxicity
1) Confidence 0.39 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20519843 Disease Relevance 0.53 Pain Relevance 0.20
Naltrexone significantly inhibited the production of TNF-alpha induced by LPS, but not SEB in vivo.
LPS Neg (not) Positive_regulation (induced) of TNF-alpha
2) Confidence 0.19 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15265541 Disease Relevance 0.85 Pain Relevance 0.65
LPS, that predominantly induces TNF-alpha/beta in fresh murine splenocytes, is able to stimulate T lymphocytes to produce interferon-gamma (IFN-?)
LPS Positive_regulation (induces) of TNF-alpha in T lymphocytes
3) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.76 Pain Relevance 0.04

General Comments

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