INT120154

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.30
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SLC9A1) plasma membrane (SLC9A1) transcription factor binding (SLC9A1)
transmembrane transport (SLC9A1)
Anatomy Link Frequency
melanocytes 2
myocardial cell 1
internal 1
SLC9A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 2 92.68 High High
ischemia 84 91.84 High High
Paresthesia 3 47.68 Quite Low
cva 33 29.84 Quite Low
Angina 21 28.28 Quite Low
depression 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 81 91.84 High High
Reperfusion Injury 3 81.20 Quite High
Necrosis 45 73.64 Quite High
Death 36 62.56 Quite High
Ventricular Remodeling 3 61.80 Quite High
Left Ventricular Dysfunction 15 60.32 Quite High
Contracture 6 57.68 Quite High
Myocardial Infarction 138 55.80 Quite High
Rupture 3 55.68 Quite High
Vomiting 3 50.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NHE-1 is ubiquitously distributed in tissue, and is the predominant NHE isoform in the myocardial cell.
Gene_expression (distributed) of NHE-1 in myocardial cell
1) Confidence 0.47 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.69 Pain Relevance 0.12
Similar IC50 values were found in ex vivohuman platelet studies (45-72 ng/ml), with concentrations of 200 ng/ml producing 80% inhibition (internal data; Agents); the 80 and 120 mg doses in these studies inhibited NHE exchange by 90-100% shortly after administration.
Gene_expression (exchange) of NHE in internal
2) Confidence 0.41 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.38 Pain Relevance 0.10
Accordingly, trough NHE inhibition levels of 74 and 85%, respectively, were expected with the two high doses.
Gene_expression (expected) of NHE
3) Confidence 0.41 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.23 Pain Relevance 0.06
Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis showed that both Black and White melanocytes expressed mRNA and protein for NHE-1, NHE-3, NHE-5, NHE-6, and NHE-7.
Gene_expression (expressed) of NHE-1 in melanocytes
4) Confidence 0.24 Published 2004 Journal Exp. Cell Res. Section Abstract Doc Link 15265699 Disease Relevance 0 Pain Relevance 0.09
Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis showed that both Black and White melanocytes expressed mRNA and protein for NHE-1, NHE-3, NHE-5, NHE-6, and NHE-7.
Gene_expression (expressed) of NHE in melanocytes
5) Confidence 0.24 Published 2004 Journal Exp. Cell Res. Section Abstract Doc Link 15265699 Disease Relevance 0 Pain Relevance 0.09

General Comments

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