INT120164

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 36.89
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (OPCML) plasma membrane (OPCML)
Anatomy Link Frequency
brain 3
nervous system 3
T29H 2
lung 2
SW480 1
OPCML (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 88 100.00 Very High Very High Very High
metalloproteinase 6 24.40 Low Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 354 100.00 Very High Very High Very High
Nasopharynx Cancer 874 99.88 Very High Very High Very High
Cancer 2428 99.84 Very High Very High Very High
Carcinoma 494 99.84 Very High Very High Very High
Adenocarcinoma 167 99.32 Very High Very High Very High
Esophageal Cancer 116 99.02 Very High Very High Very High
Stress 685 98.88 Very High Very High Very High
Ovarian Cancer 171 98.84 Very High Very High Very High
Lymphatic System Cancer 572 97.64 Very High Very High Very High
Shock 77 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the in silico identified genes is OPCML (opioid binding protein/cell adhesion molecule-like gene), also known as OBCAM (opioid binding cell adhesion molecule), belonging to the IgLON (OPCML, LSAMP, NEGR1 and HNT) family of glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules that are highly expressed in the nervous system [15]–[18] and involved in cell adhesion and cell-cell recognition [19].
Gene_expression (expressed) of IgLON in nervous system associated with opioid and adhesions
1) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.57 Pain Relevance 0.20
Interestingly, OPCML-v2 could not be activated in any drug treated cell line or DKO cell line (Fig. 4A, 4B), suggesting that the expression of OPCML-v2, being tissue-specific, is controlled by other intrinsic mechanism(s), and that its silencing in multiple carcinoma cell lines is controlled by methylation-independent mechanism or, less likely, that its upregulation level is below the limit of detection.


Gene_expression (expression) of OPCML-v2 associated with carcinoma
2) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.62 Pain Relevance 0
One of the in silico identified genes is OPCML (opioid binding protein/cell adhesion molecule-like gene), also known as OBCAM (opioid binding cell adhesion molecule), belonging to the IgLON (OPCML, LSAMP, NEGR1 and HNT) family of glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules that are highly expressed in the nervous system [15]–[18] and involved in cell adhesion and cell-cell recognition [19].
Gene_expression (expressed) of OPCML in nervous system associated with opioid and adhesions
3) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.56 Pain Relevance 0.20
We found that the expression of OPCML-v1 was dramatically elevated in cell lines with an unmethylated promoter, after exposure to various stresses, such as heat shock, UV irradiation and H2O2 treatment.
Gene_expression (expression) of OPCML-v1 associated with stress and shock
4) Confidence 0.77 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.20 Pain Relevance 0
Furthermore, although singly transfected cell lines have little effect on neurite outgrowth, CHO cell lines expressing both CEPU-1 and OBCAM (Diglon-CO) inhibit neurite outgrowth from cerebellar granule cells.
Gene_expression (expressing) of OBCAM in neurite
5) Confidence 0.70 Published 2004 Journal J. Cell. Sci. Section Abstract Doc Link 15265982 Disease Relevance 0.36 Pain Relevance 0.07
p53 could induce OPCML expression in the H1299 cell line with a partially methylated promoter, in a dosage-dependent manner (Fig. 7C).
Gene_expression (expression) of OPCML
6) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.21 Pain Relevance 0
Notably, expression of OPCML-v2 remained undetectable in virtually all cell lines evaluated, including normal cell lines.
Gene_expression (expression) of OPCML-v2
7) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.63 Pain Relevance 0
Using primers specific to the common exons of OPCML transcripts, we found the expression of OPCML in several tumor cell lines (Hep3B, H292, SW480, L1236), where the OPCML-v1 and v2 were totally silenced (Fig. 1F), indicating transcription of OPCML from alternative unknown promoters.
Gene_expression (expression) of OPCML in SW480 associated with cancer
8) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.15 Pain Relevance 0
The treatment resulted in the restoration of OPCML-v1 expression in all tumor cell lines (Fig. 4A).
Gene_expression (expression) of OPCML-v1 associated with cancer
9) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.62 Pain Relevance 0
Ecotopic expression of OPCML led to significant inhibition of both anchorage-dependent and -independent growth of carcinoma cells with endogenous silencing.


Gene_expression (expression) of OPCML associated with carcinoma
10) Confidence 0.68 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2500176 Disease Relevance 1.36 Pain Relevance 0
Pharmacologic and genetic demethylation restored OPCML-v1 expression
Gene_expression (expression) of OPCML-v1
11) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.75 Pain Relevance 0
Whereas OPCML-v1 was widely expressed in normal adult tissues, OPCML-v2 showed a more tissue-specific expression profile, being highly expressed in few tissues including brain.
Gene_expression (expressed) of OPCML-v1 in brain
12) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.35 Pain Relevance 0
In contrast to its expression in adult tissues, OPCML-v2 was expressed at moderate to high levels in all fetal tissues except for placenta.
Neg (except) Gene_expression (expressed) of OPCML-v2 in placenta
13) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.28 Pain Relevance 0
In summary, we found that the expression of OPCML-v1 (NM_002545), a major transcript of this TSG, is frequently silenced or down-regulated in multiple tumors.
Gene_expression (expression) of OPCML-v1 associated with cancer
14) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.08 Pain Relevance 0
In addition, ectopic expression of OPCML in carcinoma cells lacking its expression led to dramatic anchorage-dependent and –independent growth inhibition.
Gene_expression (expression) of OPCML associated with carcinoma
15) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.09 Pain Relevance 0
OPCML-v1 was widely expressed in all normal adult and fetal tissues except for placenta and peripheral blood mononuclear cells (PBMC), though at varying levels (highly expressed in brain, kidney, spleen, stomach, trachea, testis, cervix, ovary and prostate, and weakly in lung, breast, and bone marrow) (Fig. 1E).
Neg (except) Gene_expression (expressed) of OPCML-v1 in bone marrow
16) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0 Pain Relevance 0
It was found that OPCML-v1 expression was dramatically reduced or completely silenced in multiple carcinoma cell lines of nasopharynx, esophagus, breast, cervix, stomach, lung, colon, liver and prostate, as well as in virtually all lymphoma cell lines examined (Fig. 2C and Figure S1), but readily detected in glioma cell lines (Fig. 2D).
Gene_expression (expression) of OPCML-v1 in stomach associated with lymphatic system cancer, carcinoma and glioma
17) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.64 Pain Relevance 0
Previously, OPCML was shown to be strongly expressed in brain and normal ovarian epithelia [20].
Gene_expression (expressed) of OPCML in brain
18) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0 Pain Relevance 0
Pharmacological and genetic demethylation restored OPCML expression, indicating a direct epigenetic silencing.
Gene_expression (expression) of OPCML
19) Confidence 0.68 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2500176 Disease Relevance 1.44 Pain Relevance 0
Among the IgLON family, OPCML was the first member reported to possess tumor suppressor functions in epithelial ovarian cancer, being frequently silenced genetically and epigenetically at the early step of ovarian carcinogenesis [20].
Gene_expression (family) of OPCML associated with cancer and ovarian cancer
20) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.97 Pain Relevance 0

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