INT120190

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.17
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl4) extracellular region (Ccl4)
Anatomy Link Frequency
hepatocytes 2
Ccl4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 16 98.48 Very High Very High Very High
Inflammation 38 98.08 Very High Very High Very High
Glutamate 2 90.92 High High
fibrosis 6 89.76 High High
Paracetamol 4 85.36 High High
alcohol 13 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 10 99.62 Very High Very High Very High
Stress 23 99.24 Very High Very High Very High
INFLAMMATION 42 98.08 Very High Very High Very High
Apoptosis 38 97.36 Very High Very High Very High
Injury 60 96.92 Very High Very High Very High
Disorder Of Lipid Metabolism 6 93.56 High High
Cirrhosis 6 89.76 High High
Cancer 8 86.92 High High
Hepatotoxicity 41 86.84 High High
Body Weight 40 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HV pretreatment (0.5 and 1.0 ml/kg, p.o.) significantly (P < 0.001) reduced CCl4 or PC-induced elevations of the levels of SGOT, SGPT, ALP and TBARS, while the reduced concentration of SOD due to CCl4 or PC was reversed.
Negative_regulation (reduced) of CCl4
1) Confidence 0.41 Published 2003 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 15266956 Disease Relevance 0.25 Pain Relevance 0.25
Therefore, it is suggested that T3 suppresses the necrosis of hepatocytes by inhibition of CCl4-induced lipid peroxidation.
Negative_regulation (inhibition) of CCl4 in hepatocytes associated with necrosis
2) Confidence 0.40 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2933434 Disease Relevance 0.59 Pain Relevance 0.04
The present study revealed that prior administration of natansnin (both concentrations) significantly decreased the CCl4 induced oxidative stress and cellular degeneration.


Negative_regulation (decreased) of CCl4 associated with stress
3) Confidence 0.37 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 1.13 Pain Relevance 0.17
Prior administration of natansnin decreased the cellular degeneration, compared to CCl4 treated hepatocytes.
Negative_regulation (decreased) of CCl4 in hepatocytes
4) Confidence 0.37 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.23 Pain Relevance 0
It has also been shown that a single treatment of rats with CCl4 causes disruption of hepatic antioxidant defense systems associated with antioxidants such as reduced glutathione (GSH) and antioxidant enzymes such as superoxide dismutase (SOD), an enzyme to scavenge O2·?
Negative_regulation (disruption) of CCl4
5) Confidence 0.36 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 0.49 Pain Relevance 0
-Toc + CCl4 and T3 mix + CCl4 groups was decreased in comparison with the CCl4 group.
Negative_regulation (decreased) of CCl4
6) Confidence 0.35 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2933434 Disease Relevance 0.48 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox