INT120202

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.78
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Ern1) endoplasmic reticulum (Ern1) kinase activity (Ern1)
response to stress (Ern1)
Ern1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 87.08 High High
Inflammation 7 86.68 High High
Abeta 4 78.24 Quite High
cINOD 3 25.00 Low Low
Catecholamine 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 15 99.98 Very High Very High Very High
Alzheimer's Dementia 9 99.12 Very High Very High Very High
Coronary Heart Disease 1 98.92 Very High Very High Very High
Disease 69 97.64 Very High Very High Very High
Iron Overload 1 93.16 High High
Dementia 2 90.80 High High
INFLAMMATION 9 86.68 High High
Amyloid Plaque 1 72.24 Quite High
Targeted Disruption 16 25.00 Low Low
Viral Meningitis 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To explore if alteration in protein trafficking and folding was involved in myocardial dysfunction in APP/PS1 mice, protein expression of the ER stress markers IRE-1?
Gene_expression (markers) of IRE-1 associated with stress and coronary heart disease
1) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.33 Pain Relevance 0
Also the presence of an Iron-Responsive Element (IRE) in the 5'UTR of the Amyloid Precursor Protein transcript (APP 5'UTR) provided the first molecular biological support for the current model that APP of AD is a metaloprotein.
Gene_expression (presence) of IRE associated with alzheimer's dementia and disease
2) Confidence 0.11 Published 2004 Journal Curr Drug Targets Section Abstract Doc Link 15270200 Disease Relevance 1.45 Pain Relevance 0.21

General Comments

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