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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.17
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hcrtr1) signal transducer activity (Hcrtr1)
Anatomy Link Frequency
hypothalamus 1
Hcrtr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 3 82.88 Quite High
Central nervous system 5 76.16 Quite High
antagonist 11 75.56 Quite High
depression 1 74.08 Quite High
anesthesia 1 69.64 Quite High
Eae 13 56.68 Quite High
Neuropeptide 3 25.00 Low Low
adenocard 1 17.84 Low Low
Dopamine 5 16.96 Low Low
Neurobehavioral 1 16.16 Low Low
Disease Link Frequency Relevance Heat
Sleep Disorders 53 99.56 Very High Very High Very High
Hypersomnia 87 99.26 Very High Very High Very High
Sleep Paralysis 2 86.96 High High
Hallucination 2 86.12 High High
Depression 1 74.08 Quite High
Ulcers 1 73.48 Quite High
Aging 1 44.20 Quite Low
Apnoea 44 32.16 Quite Low
Cerebral Hypoxia 1 9.56 Low Low
Stress 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in the OX1R protein level in the hypothalamus could be responsible for orexin-A's lack of stimulation of food intake in old rats.
Negative_regulation (decrease) of OX1R in hypothalamus
1) Confidence 0.58 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15271651 Disease Relevance 0 Pain Relevance 0.14
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats


Negative_regulation (Inhibition) of hypocretin-1
2) Confidence 0.24 Published 2008 Journal Psychopharmacology (Berl) Section Title Doc Link PMC2668563 Disease Relevance 0 Pain Relevance 0.09
Narcolepsy with cataplexy is associated with a deficiency of orexin-A, also known as hypocretin-1, a hypothalamic peptide implicated in energy homeostasis and arousal (Sakurai 2007).

Negative_regulation (deficiency) of hypocretin-1 associated with hypersomnia and sleep disorders
3) Confidence 0.03 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 1.17 Pain Relevance 0.11

General Comments

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