INT120216

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR2) transmembrane transport (RYR2)
Anatomy Link Frequency
heart 1
RYR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 95.88 Very High Very High Very High
Pain 1 85.36 High High
Calcium channel 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Muscle Disease 1 99.42 Very High Very High Very High
Malignant Hyperthermia 2 98.84 Very High Very High Very High
Myocardial Infarction 1 97.60 Very High Very High Very High
Disease 2 89.28 High High
Epilepsy 1 87.68 High High
Pain 1 85.36 High High
Cancer 1 84.64 Quite High
Heart Disease 1 78.96 Quite High
Arrhythmogenic Right Ventricular Dysplasia 1 78.28 Quite High
Heart Rate Under Development 1 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Defects in RyR1 cause malignant hyperthermia and a spectrum of myopathies in skeletal muscle; whereas RyR2 dysregulation can result in fatal cardiac arrhythmias and is involved in heart failure.
Regulation (dysregulation) of RyR2 in heart associated with muscle disease, malignant hyperthermia and myocardial infarction
1) Confidence 0.28 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20097179 Disease Relevance 0.71 Pain Relevance 0.12
Succinylcholine and volatile anesthetics did not have a clinically significant effect on RyR2 defects.
Regulation (effect) of RyR2
2) Confidence 0.14 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15271719 Disease Relevance 0.32 Pain Relevance 0.10

General Comments

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