INT120220

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.82
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
node 1
ANIB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 8 100.00 Very High Very High Very High
Gabapentin 21 99.98 Very High Very High Very High
Regional anesthesia 1 76.64 Quite High
Inflammation 21 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 8 100.00 Very High Very High Very High
Phobia 1 99.98 Very High Very High Very High
Breast Cancer 492 99.68 Very High Very High Very High
Sleep Disorders 9 98.48 Very High Very High Very High
Cancer 365 87.68 High High
Brain Tumor 2 78.64 Quite High
Reprotox - General 1 5 49.52 Quite Low
Ductal Carcinoma 8 34.16 Quite Low
Disease 65 5.00 Very Low Very Low Very Low
Metastasis 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The peptides Boc-Ac6c-Gpn-OMe 1 and Boc-Gpn-Aib-Gpn-Aib-OMe 2 provide examples of C7 conformation; peptides Boc-Gpn-Aib-OH 3, Boc-Ac6c-Gpn-OH 4, Boc-Val-Pro-Gpn-OH 5, Piv-Pro-Gpn-Val-OMe 6, and Boc-Gpn-Gpn-Leu-OMe 7 provide examples of C9 conformation; peptide Boc-Ala-Aib-Gpn-Aib-Ala-OMe 8 provides an example of C12 conformation and peptides Boc-betaLeu-Gpn-Val-OMe 9 and Boc-betaPhe-Gpn-Phe-OMe 10 provide examples of C13 conformation.
Gene_expression (provide) of Aib associated with gabapentin
1) Confidence 0.65 Published 2007 Journal J. Am. Chem. Soc. Section Abstract Doc Link 17348653 Disease Relevance 0 Pain Relevance 1.63
However, in the ER-negative and node-negative subsets, high AIB1 expression was associated with poor patient outcome (P = 0.02 and P = 0.007 respectively).61 There was significant positive correlation between AIB1 and ER/PR status and with other cofactors (TIF2 and NCoR), but not with HER2/neu status.
Gene_expression (expression) of AIB1 in node
2) Confidence 0.25 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.20 Pain Relevance 0
Harigopal et al studied the prognostic significance of AIB1, TIF2 and NCoR protein expression in 670 breast cancer specimens by breast tissue microarray, and demonstrated the relationship of coregulatory proteins to ER, PR and HER2/neu.61 High AIB1 expression was associated with poor patient outcome (P = 0.002), while no association was noted for TIF2 (P = 0.376) or NCoR (P = 0.12).
Gene_expression (expression) of AIB1 associated with breast cancer
3) Confidence 0.25 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.26 Pain Relevance 0
Harigopal et al studied the prognostic significance of AIB1, TIF2 and NCoR protein expression in 670 breast cancer specimens by breast tissue microarray, and demonstrated the relationship of coregulatory proteins to ER, PR and HER2/neu.61 High AIB1 expression was associated with poor patient outcome (P = 0.002), while no association was noted for TIF2 (P = 0.376) or NCoR (P = 0.12).
Gene_expression (expression) of AIB1 associated with breast cancer
4) Confidence 0.25 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.24 Pain Relevance 0
Thus, high AIB1 expression predicted worse overall survival in this study, suggesting that AIB1 may be involved in breast carcinogenesis.


Gene_expression (expression) of AIB1
5) Confidence 0.25 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.13 Pain Relevance 0
We then assayed similarly expression levels for nuclear coactivators AIB1 [16], CBP [17], p300 [18], p/CIP [19], RAC3 [20], RIP140 [21], SRC1 [22], TIF1 [23], TIF2 [24] and TRIP1 [25].
Gene_expression (expression) of AIB1
6) Confidence 0.20 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0
The fear of producing CO(2) retention and a secondary increase of intracranial pressure (ICP) sometimes precludes the use of sedation for the spontaneously breathing patient in the presence of an intracranial space-occupying lesion.
Gene_expression (producing) of intracranial pressure associated with phobia, cva and sleep disorders
7) Confidence 0.02 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15271741 Disease Relevance 0.98 Pain Relevance 0.29

General Comments

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