INT120226

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.54
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxadr) extracellular region (Cxadr) cell adhesion (Cxadr)
mitochondrion organization (Cxadr) plasma membrane (Cxadr) nucleus (Cxadr)
Anatomy Link Frequency
CAR 3
ventricle 1
atrium 1
Cxadr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 5 99.16 Very High Very High Very High
anesthesia 18 87.92 High High
Inflammation 8 62.56 Quite High
Paracetamol 1 50.16 Quite High
Antiemetics 1 25.00 Low Low
metalloproteinase 26 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 227 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 10 97.52 Very High Very High Very High
Vomiting 1 95.68 Very High Very High Very High
Heart Disease 9 95.20 Very High Very High Very High
Infection 8 90.16 High High
Cardiovascular Disease 22 83.80 Quite High
Arrhythmia Under Development 57 80.72 Quite High
Arrhythmias 2 Under Development 12 75.68 Quite High
INFLAMMATION 10 62.56 Quite High
Atherosclerosis 40 51.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocks of a higher degree were present from 4 wk after induction of the CAR KO (Fig. 2 F), including partial failure of AV conduction (AVB II°, 25%) or total dissociation of atrial and ventricular rhythms (AVB III°, 37.5%).


Spec (partial) Positive_regulation (induction) of CAR in CAR associated with targeted disruption
1) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.77 Pain Relevance 0.15
We have generated a heart-specific inducible CAR knockout (KO) and found impaired electrical conduction between atrium and ventricle that increased with progressive loss of CAR.
Positive_regulation (inducible) of CAR in ventricle associated with targeted disruption
2) Confidence 0.41 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2556793 Disease Relevance 0.37 Pain Relevance 0
We have generated a heart-specific inducible CAR knockout (KO) and found impaired electrical conduction between atrium and ventricle that increased with progressive loss of CAR.
Positive_regulation (inducible) of CAR in atrium associated with targeted disruption
3) Confidence 0.14 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2556793 Disease Relevance 0.37 Pain Relevance 0
Meclizine increases mCAR transactivation in a dose-dependent manner.
Positive_regulation (increases) of mCAR
4) Confidence 0.11 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.10 Pain Relevance 0.27
Ad-mediated gene therapy is dependent on the level of the coxsackie-adenovirus receptor (CAR) and integrins (?
Positive_regulation (dependent) of coxsackie-adenovirus receptor in CAR
5) Confidence 0.08 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.46 Pain Relevance 0.03
Ad-mediated gene therapy is dependent on the level of the coxsackie-adenovirus receptor (CAR) and integrins (?
Positive_regulation (dependent) of CAR in CAR
6) Confidence 0.08 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.46 Pain Relevance 0.03

General Comments

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