INT120227

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 8.02
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxadr) extracellular region (Cxadr) cell adhesion (Cxadr)
mitochondrion organization (Cxadr) plasma membrane (Cxadr) nucleus (Cxadr)
Anatomy Link Frequency
CAR 19
Cxadr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 5 99.98 Very High Very High Very High
addiction 17 98.16 Very High Very High Very High
Bioavailability 5 95.60 Very High Very High Very High
Central nervous system 36 91.36 High High
imagery 77 87.44 High High
Dopamine 72 80.80 Quite High
midbrain 12 80.72 Quite High
Substantia nigra 72 78.32 Quite High
Potency 45 77.16 Quite High
dexamethasone 52 56.68 Quite High
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 171 99.52 Very High Very High Very High
Disease 87 99.52 Very High Very High Very High
Vomiting 2 99.02 Very High Very High Very High
Colon Cancer 96 98.94 Very High Very High Very High
Cancer 442 97.12 Very High Very High Very High
Targeted Disruption 767 96.20 Very High Very High Very High
Infection 58 95.36 Very High Very High Very High
Heart Disease 27 93.00 High High
Parkinson's Disease 60 89.72 High High
Hypersensitivity 9 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Not only does this have implications for CAR as a potential diagnostic marker for familial cases of AV block but it might also help explain how virus proteins or autoantibodies that interact with tight junction proteins, such as CAR, can cause arrhythmia (30).
CAR Binding (interact) of in CAR associated with arrhythmia under development
1) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.76 Pain Relevance 0
Shedding of virus proteins from infected cells is an important mechanism to disrupt CAR–CAR interaction at the tight junction and facilitate virus passing epithelial barriers (31).
CAR Binding (interaction) of in CAR
2) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.79 Pain Relevance 0
Shedding of virus proteins from infected cells is an important mechanism to disrupt CAR–CAR interaction at the tight junction and facilitate virus passing epithelial barriers (31).
CAR Binding (interaction) of in CAR
3) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.79 Pain Relevance 0
At this time, there is no genetic defect of CAR associated with human disease, but our findings would suggest tight junction proteins as potential disease genes in genetic forms of isolated AV block.
CAR Binding (associated) of in CAR associated with disease
4) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.77 Pain Relevance 0
The tight junction protein CAR regulates cardiac conduction and cell–cell communication

The Coxsackievirus-adenovirus receptor (CAR) is known for its role in virus uptake and as a protein of the tight junction.

CAR Binding (known) of in CAR
5) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Title Doc Link PMC2556793 Disease Relevance 0.34 Pain Relevance 0
The tight junction protein CAR regulates cardiac conduction and cell–cell communication

The Coxsackievirus-adenovirus receptor (CAR) is known for its role in virus uptake and as a protein of the tight junction.

Coxsackievirus-adenovirus receptor Binding (known) of in CAR
6) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Title Doc Link PMC2556793 Disease Relevance 0.34 Pain Relevance 0
This includes reduced expression of ZO-1, an adaptor protein that binds both CAR and connexins (Fig. 6 A) (8, 21).
CAR Binding (binds) of in CAR
7) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.39 Pain Relevance 0
The primary antibodies used were the following: rat anti-HCN4 (Abcam) and anti-CAR (rabbit polyclonal, raised against the Fc fusion protein containing the CA extracellular domain), anti-CAR (rabbit polyclonal; Santa Cruz Biotechnology, Inc.), anti–N-cadherin (mouse monoclonal; Invitrogen), anti-Cx43 (mouse monoclonal; Invitrogen), and anti–?
anti-CAR Binding (rat) of in CAR
8) Confidence 0.31 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.08 Pain Relevance 0.04
The primary antibodies used were the following: rat anti-HCN4 (Abcam) and anti-CAR (rabbit polyclonal, raised against the Fc fusion protein containing the CA extracellular domain), anti-CAR (rabbit polyclonal; Santa Cruz Biotechnology, Inc.), anti–N-cadherin (mouse monoclonal; Invitrogen), anti-Cx43 (mouse monoclonal; Invitrogen), and anti–?
anti-CAR Binding (rat) of in CAR
9) Confidence 0.31 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.08 Pain Relevance 0.04
After binding to CAR, adenoviral penton base Arg-Gly-Asp (RGD) motif interacts with cellular ?
CAR Binding (binding) of in CAR
10) Confidence 0.30 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936307 Disease Relevance 0.18 Pain Relevance 0.04
In this regard, the tropism of Ad5-based vectors is determined by direct binding of the Ad5 fiber protein to its primary cellular receptor, the coxsackie and adenovirus receptor (CAR) [19], [20].
adenovirus receptor Binding (binding) of in CAR
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.17 Pain Relevance 0.16
The cellular tropism of Ad serotype 5 (Ad5)–based vectors is regulated by the Ad attachment protein binding to its primary cellular receptor, the coxsackie and adenovirus receptor (CAR).
CAR Binding (binding) of in CAR
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2941453 Disease Relevance 0.32 Pain Relevance 0.22
The cellular tropism of Ad serotype 5 (Ad5)–based vectors is regulated by the Ad attachment protein binding to its primary cellular receptor, the coxsackie and adenovirus receptor (CAR).
adenovirus receptor Binding (binding) of in CAR
13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2941453 Disease Relevance 0.32 Pain Relevance 0.22
In the absence of CAR, Lys-Lys-Thr-Lys (KKTK) domain in the fiber shaft has been suggested to play a major role in viral internalization via low affinity binding with HSPG[27-29] and a mutation in this domain has been shown to decrease viral tropism towards hepatocytes[27,29].
CAR Binding (binding) of in CAR
14) Confidence 0.22 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936307 Disease Relevance 0.20 Pain Relevance 0.04
Targeting adenovirus towards av integrins is an effective way to increase tumor cell transduction in vitro, as was shown by an increased transduction of colorectal cancer cells with RGD targeted vectors, even if the vector interaction with CAR and HSPGs was abrogated.
CAR Binding (interaction) of in CAR associated with cancer and colon cancer
15) Confidence 0.22 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936307 Disease Relevance 0.97 Pain Relevance 0.12
Numerous papers suggest that other entry mechanisms in addition to CAR binding are important in mediating adenovirus serotype 5 distribution in vivo[21,32].
CAR Binding (binding) of in CAR
16) Confidence 0.22 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936307 Disease Relevance 0.60 Pain Relevance 0.07
We therefore performed western blot analysis using an antibody that recognizes both human and mouse CAR (Santa Cruz, sc-15405), and observed substantial regional variation in the abundance of endogenous mCAR protein in adult wild type mice.
CAR Binding (recognizes) of in CAR
17) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.26 Pain Relevance 0.14
For example, it is increasingly accepted that while binding to CAR is an important determinant of transduction in vitro, other regions of the fiber may be even more relevant in vivo [38].
CAR Binding (binding) of in CAR
18) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.32 Pain Relevance 0.21
Syn3 acts as a transfer enhancer that circumvents the need for CAR binding (119).A comparison of intravesical instillation (single administration) of viral IFN gene therapy (Ad-IFN/Syn3, recombinant replication-deficient adenovirus containing human IFN alpha-2b gene and Syn3) to intravesical IFN showed that IFN gene therapy resulted in much higher IFN concentrations (1000-times higher peak level) that were sustained for a much longer duration (96 hr or longer vs undetectable at 24 hr) in urothelial tissues (121).
CAR Binding (binding) of in CAR
19) Confidence 0.08 Published 2008 Journal Pharm Res Section Body Doc Link PMC2440939 Disease Relevance 0.24 Pain Relevance 0
Here we identify the widely used antiemetic meclizine (Antivert; Bonine) as both an agonist ligand for mCAR and an inverse agonist for hCAR.
mCAR Binding (ligand) of associated with vomiting and agonist
20) Confidence 0.07 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.10 Pain Relevance 0.22

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