INT120229

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.04
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ncoa1) nucleus (Ncoa1) transferase activity, transferring acyl groups (Ncoa1)
DNA binding (Ncoa1) signal transducer activity (Ncoa1)
Anatomy Link Frequency
gonadal 1
Ncoa1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 63 98.68 Very High Very High Very High
Paracetamol 5 64.00 Quite High
tolerance 37 61.12 Quite High
antagonist 5 51.04 Quite High
cINOD 6 26.36 Quite Low
Antiemetics 1 25.00 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 10 99.12 Very High Very High Very High
Obesity 100 95.72 Very High Very High Very High
Targeted Disruption 54 94.00 High High
Vomiting 1 89.84 High High
Weight Gain 23 75.04 Quite High
Retinoblastoma 2 66.20 Quite High
Hepatotoxicity 3 62.24 Quite High
Impaired Glucose Tolerance 37 61.76 Quite High
Embryonic Lethality 5 54.80 Quite High
Placental Insufficiency 1 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
involves the AF1 domain and ligand-independent interactions with the coactivators SRC1 and TIF2.
SRC1 Binding (interactions) of
1) Confidence 0.35 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.21 Pain Relevance 0.03
Binding of SRC1 and TIF2 to the adiponectin promoter was enhanced in gonadal fat from ?
SRC1 Binding (Binding) of in gonadal
2) Confidence 0.26 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.15 Pain Relevance 0.03
Like the mCAR agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, meclizine stimulates binding of steroid receptor coactivator 1 to the murine receptor in vitro.
steroid receptor coactivator 1 Binding (binding) of associated with agonist
3) Confidence 0.17 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.15 Pain Relevance 0.28
SRC1, as highlighted by the phenotype of SRC1-deficient mice which
SRC1 Binding (phenotype) of
4) Confidence 0.13 Published 2007 Journal PPAR Research Section Body Doc Link PMC1783742 Disease Relevance 0.36 Pain Relevance 0.10
DN1 did not affect the recruitment of TRAP220 or SRC-1 to the p21WAF1 promoter.
SRC-1 Neg (not) Binding (recruitment) of
5) Confidence 0.05 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.07 Pain Relevance 0
NCoA6(NRC) or SRC-1 was shown to primarily bind to TR?
SRC-1 Binding (bind) of
6) Confidence 0.05 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Two coactivators that have histone acetyltransferase activity, steroid receptor coactivator-1 (SRC-1) and CREB binding protein/p300 (CBP), can bind to PPARs in a ligand-dependent manner.
coactivator-1 Binding (bind) of
7) Confidence 0.03 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.11 Pain Relevance 0

General Comments

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