INT120232

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.08
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr1i3) cytoskeleton (Nr1i3) nucleus (Nr1i3)
DNA binding (Nr1i3) cytoplasm (Nr1i3)
Anatomy Link Frequency
CAR 5
hepatocytes 1
Nr1i3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 3 97.48 Very High Very High Very High
Bile 117 97.16 Very High Very High Very High
agonist 37 92.64 High High
addiction 1 73.20 Quite High
antagonist 21 45.92 Quite Low
Antiemetics 2 25.00 Low Low
Inflammation 51 5.00 Very Low Very Low Very Low
Crohn's disease 18 5.00 Very Low Very Low Very Low
antidepressant 9 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 9 98.40 Very High Very High Very High
Paralysis 1 96.72 Very High Very High Very High
Vomiting 5 85.12 High High
Hepatomegaly 1 78.72 Quite High
Increased Venous Pressure Under Development 3 72.08 Quite High
Hyperlipidemia 9 71.28 Quite High
Embryonic Lethality 1 60.76 Quite High
Disorder Of Lipid Metabolism 12 38.44 Quite Low
Rickets 24 16.96 Low Low
Cardiovascular Disease 3 5.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meclizine administration to mice increases expression of CAR target genes in a CAR-dependent manner.
Gene_expression (expression) of CAR in CAR
1) Confidence 0.75 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.15 Pain Relevance 0.28
In contrast, meclizine suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR.
Gene_expression (expression) of CAR in hepatocytes
2) Confidence 0.58 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.16 Pain Relevance 0.28
The orphan receptor CAR (NR1I3) was initially isolated and shown to activate a DR-5 type of retinoid acid response element (?
Gene_expression (isolated) of NR1I3 in CAR
3) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.05
The orphan receptor CAR (NR1I3) was initially isolated and shown to activate a DR-5 type of retinoid acid response element (?
Gene_expression (receptor) of NR1I3 in CAR
4) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.05
The orphan receptor CAR (NR1I3) was initially isolated and shown to activate a DR-5 type of retinoid acid response element (?
Gene_expression (shown) of NR1I3 in CAR
5) Confidence 0.42 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.14 Pain Relevance 0.05
Studies with adenovirally driven EGFP-CAR expression in liver demonstrated that, unlike PBP, the absence of PRIP does not prevent phenobarbital-mediated nuclear translocation/retention of the receptor CAR in liver in vivo and cultured hepatocytes in vitro.
Gene_expression (expression) of CAR in CAR
6) Confidence 0.38 Published 2007 Journal Gene Expr. Section Abstract Doc Link 17605299 Disease Relevance 0.33 Pain Relevance 0.13

General Comments

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