INT120234

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 2.21
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp3a11) endoplasmic reticulum (Cyp3a11)
Anatomy Link Frequency
liver 3
intestine 3
hepatocytes 2
Cyp3a11 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 18 100.00 Very High Very High Very High
Bile 234 95.32 Very High Very High Very High
agonist 59 91.52 High High
Inflammation 103 75.64 Quite High
Antiemetics 1 25.00 Low Low
Inflammatory stimuli 6 8.96 Low Low
antagonist 42 5.00 Very Low Very Low Very Low
Crohn's disease 36 5.00 Very Low Very Low Very Low
antidepressant 18 5.00 Very Low Very Low Very Low
dexamethasone 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 19 96.36 Very High Very High Very High
Toxicity 25 95.84 Very High Very High Very High
Targeted Disruption 127 95.32 Very High Very High Very High
Breast Cancer 56 83.36 Quite High
Vomiting 7 79.92 Quite High
Inflammatory Bowel Disease 192 76.40 Quite High
Apoptosis 48 71.00 Quite High
Rickets 48 67.60 Quite High
Cancer 115 59.44 Quite High
Necrosis 7 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is well known that drugs capable of inducing expression of CYP3A genes are likely to lead to interactions with other drugs.
Positive_regulation (inducing) of Gene_expression (expression) of CYP3A
1) Confidence 0.46 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0 Pain Relevance 0.03
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Positive_regulation (observed) of Gene_expression (expression) of Cyp3a11 associated with paracetamol
2) Confidence 0.45 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.44 Pain Relevance 1.12
In contrast, meclizine suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR.
Positive_regulation (phenobarbital-induced) of Gene_expression (expression) of CYP3A11 in hepatocytes
3) Confidence 0.35 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.17 Pain Relevance 0.29
Variation in CYP3A expression may lead to important differences in drug metabolism, leading to clinically significant differences in drug toxicities and response.
Positive_regulation (Variation) of Gene_expression (expression) of CYP3A associated with toxicity
4) Confidence 0.33 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.18 Pain Relevance 0
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Positive_regulation (induced) of Gene_expression (expression) of CYP3A11 in intestine
5) Confidence 0.33 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05
Activation of SXR by these sterol compounds induces CYP3A expression and provides an alternative pathway for sterol clearance in CYP27A1 null mice [Dussault et al., 2003; Goodwin et al., 2003].
Positive_regulation (induces) of Gene_expression (expression) of CYP3A
6) Confidence 0.33 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.11 Pain Relevance 0.37
The relatively modest differences in the response of SXR harboring non-synonymous SNPs to ligands suggest that these SNPs are probably not the sole factors mediating variations in CYP3A expression.
Neg (not) Positive_regulation (mediating) of Gene_expression (expression) of CYP3A
7) Confidence 0.31 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.27 Pain Relevance 0.08
No differences in the upregulation of cytochrome P450 gene expression (CYP1A2, CYP2B10, CYP3A11 and CYP2E1) were seen following PB or TCPOBOP treatment between NCoA6(PRIP)+/+ or liver NCoA6(PRIP)-/- conditional knockout mice.
Positive_regulation (upregulation) of Gene_expression (expression) of CYP3A11 in liver associated with targeted disruption
8) Confidence 0.25 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.73 Pain Relevance 0.16
Furthermore, feeding WT mice with diet containing the mouse SXR ligand, PCN, for two weeks strongly induced SXR target genes CYP3A11, GSTA1, and MDR1a expression, but failed to induce CYP24 expression in both liver and intestine (Zhou, C., unpublished observation).
Positive_regulation (induced) of in liver Gene_expression (expression) of CYP3A11 in intestine
9) Confidence 0.11 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.16 Pain Relevance 0.05

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