INT120260

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.33
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Galr2) signal transducer activity (Galr2)
Anatomy Link Frequency
spinal 2
neurons 1
substantia gelatinosa 1
Galr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 2 99.84 Very High Very High Very High
Analgesic 4 99.80 Very High Very High Very High
substantia gelatinosa 8 99.68 Very High Very High Very High
agonist 17 99.20 Very High Very High Very High
antagonist 4 99.00 Very High Very High Very High
Serotonin 2 98.84 Very High Very High Very High
sSRI 1 98.84 Very High Very High Very High
fluoxetine 1 98.64 Very High Very High Very High
qutenza 23 98.00 Very High Very High Very High
Antinociceptive 4 97.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 99.64 Very High Very High Very High
Nociception 19 99.04 Very High Very High Very High
Ganglion Cysts 12 96.24 Very High Very High Very High
Inflammatory Pain 3 89.36 High High
Pain 1 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These diverse actions of GalR1 and GalR2 activation on both inhibitory and excitatory neurons are discussed in relation to the known spinal antinociceptive and pro-nociceptive actions of galanin, to the possible association of GalR1 with the inhibitory G-protein, G(i/o) and to report that GalR2 activation suppresses Ca2+ channel currents.
Positive_regulation (activation) of GalR2 in spinal associated with nociception and antinociceptive
1) Confidence 0.69 Published 2008 Journal Pain Section Abstract Doc Link 17910903 Disease Relevance 0.17 Pain Relevance 0.28
These diverse actions of GalR1 and GalR2 activation on both inhibitory and excitatory neurons are discussed in relation to the known spinal antinociceptive and pro-nociceptive actions of galanin, to the possible association of GalR1 with the inhibitory G-protein, G(i/o) and to report that GalR2 activation suppresses Ca2+ channel currents.
Positive_regulation (activation) of GalR2 in spinal associated with nociception and antinociceptive
2) Confidence 0.50 Published 2008 Journal Pain Section Abstract Doc Link 17910903 Disease Relevance 0.17 Pain Relevance 0.19
GalR2 was activated with the selective agonist, AR-M 1896 (0.5-1.0 microM).
Positive_regulation (activated) of GalR2 associated with agonist
3) Confidence 0.46 Published 2008 Journal Pain Section Abstract Doc Link 17910903 Disease Relevance 0.16 Pain Relevance 0.31
Selective stimulation of GalR1 and GalR2 in rat substantia gelatinosa reveals a cellular basis for the anti- and pro-nociceptive actions of galanin.
Positive_regulation (stimulation) of GalR2 in substantia gelatinosa associated with nociception, substantia gelatinosa and analgesic
4) Confidence 0.46 Published 2008 Journal Pain Section Title Doc Link 17910903 Disease Relevance 0.19 Pain Relevance 0.38
This effect is attributed to activation of peripheral GAL receptor 2 (GalR2) because a selective GalR2 agonist (AR-M1896) mimics the pro-nociceptive actions of GAL.
Positive_regulation (activation) of GalR2 associated with nociception and agonist
5) Confidence 0.32 Published 2004 Journal Pain Section Abstract Doc Link 15275747 Disease Relevance 0.77 Pain Relevance 1.08
Activation of galanin receptor 2 (GalR2) plays a pronociceptive role and enhances capsaicin-induced nociception in the periphery.
Positive_regulation (Activation) of galanin receptor 2 associated with nociception and qutenza
6) Confidence 0.09 Published 2008 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 18553211 Disease Relevance 0.86 Pain Relevance 0.77
Galanin is co-expressed with serotonin in approximately 40% of the DRN neurons, and galanin and GALR2 expression are elevated by antidepressants like the SSRI fluoxetine, suggesting an interaction between serotonin and galanin.
Positive_regulation (elevated) of GALR2 in neurons associated with antidepressant, ssri, serotonin and fluoxetine
7) Confidence 0.08 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17973188 Disease Relevance 0 Pain Relevance 0.46

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