INT120271

Context Info Confidence 0.01 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.71 Pain Relevance 2.46

signal transduction (Grm4) plasma membrane (Grm4) intracellular (Grm4) signal transducer activity (Grm4)

Anatomy Link Frequency spinal cord 1 dorsal root ganglion 1 spinal cord dorsal horn 1 Grm4 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 10 99.84 analgesia 4 99.54 Hyperalgesia 4 98.40 dorsal root ganglion 5 98.24 IPN 4 97.72 Glutamate receptor 4 95.56 Dorsal horn 3 93.40 Pain 8 92.84 central sensitization 3 91.68 antagonist 1 86.84

Disease Link Frequency Relevance Heat Hyperalgesia 4 98.40 Ganglion Cysts 5 98.24 Inflammatory Pain 4 97.72 Nociception 3 96.96 Pain 7 92.84

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Lumbar spinal cord was recovered from adult sheep euthanased 5 h, 1, 2, 3 and 6 days after undergoing a midline laparotomy, and processed for mGluR mRNA (real-time PCR, in situ hybridization) and protein (Western blotting). mGluR(5) mRNA was up-regulated 5 h and 1 day post-surgery in laminae I-II of the spinal cord dorsal horn. mGluR(5) protein was increased 1 day post-surgery.

Gene_expression (processed) of mGluR mRNA in spinal cord dorsal horn associated with dorsal horn and spinal cord

1) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15275788 Disease Relevance 0.50 Pain Relevance 0.77

This study characterized the temporal expression of group I (mGluR(1), mGluR(5)) and II (mGluR(2), mGluR(3)) mGluRs in spinal cord following abdominal surgery.

Gene_expression (expression) of mGluRs in spinal cord associated with spinal cord

2) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15275788 Disease Relevance 0.55 Pain Relevance 0.79

Both MS-275 and SAHA up-regulated the expression of mGlu2 receptors in the dorsal root ganglion (DRG) and spinal cord under conditions in which they caused analgesia, without changing the expression of mGlu1a, mGlu4, or mGlu5 receptors.

Gene_expression (expression) of mGlu4 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, analgesia and spinal cord

3) Confidence 0.00 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.91

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