INT120271

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.71
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm4) plasma membrane (Grm4) intracellular (Grm4)
signal transducer activity (Grm4)
Anatomy Link Frequency
spinal cord 1
dorsal root ganglion 1
spinal cord dorsal horn 1
Grm4 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 10 99.84 Very High Very High Very High
analgesia 4 99.54 Very High Very High Very High
Hyperalgesia 4 98.40 Very High Very High Very High
dorsal root ganglion 5 98.24 Very High Very High Very High
IPN 4 97.72 Very High Very High Very High
Glutamate receptor 4 95.56 Very High Very High Very High
Dorsal horn 3 93.40 High High
Pain 8 92.84 High High
central sensitization 3 91.68 High High
antagonist 1 86.84 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 98.40 Very High Very High Very High
Ganglion Cysts 5 98.24 Very High Very High Very High
Inflammatory Pain 4 97.72 Very High Very High Very High
Nociception 3 96.96 Very High Very High Very High
Pain 7 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lumbar spinal cord was recovered from adult sheep euthanased 5 h, 1, 2, 3 and 6 days after undergoing a midline laparotomy, and processed for mGluR mRNA (real-time PCR, in situ hybridization) and protein (Western blotting). mGluR(5) mRNA was up-regulated 5 h and 1 day post-surgery in laminae I-II of the spinal cord dorsal horn. mGluR(5) protein was increased 1 day post-surgery.
Gene_expression (processed) of mGluR mRNA in spinal cord dorsal horn associated with dorsal horn and spinal cord
1) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15275788 Disease Relevance 0.50 Pain Relevance 0.77
This study characterized the temporal expression of group I (mGluR(1), mGluR(5)) and II (mGluR(2), mGluR(3)) mGluRs in spinal cord following abdominal surgery.
Gene_expression (expression) of mGluRs in spinal cord associated with spinal cord
2) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15275788 Disease Relevance 0.55 Pain Relevance 0.79
Both MS-275 and SAHA up-regulated the expression of mGlu2 receptors in the dorsal root ganglion (DRG) and spinal cord under conditions in which they caused analgesia, without changing the expression of mGlu1a, mGlu4, or mGlu5 receptors.
Gene_expression (expression) of mGlu4 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, analgesia and spinal cord
3) Confidence 0.00 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.91

General Comments

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