INT12028

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1981
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 9.01
Pain Relevance 7.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
pyramidal neurons 5
hippocampus 4
neurons 3
brain 2
margin 1
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 5 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Pyramidal cell 310 99.96 Very High Very High Very High
tetrodotoxin 23 99.96 Very High Very High Very High
Hippocampus 235 99.84 Very High Very High Very High
depression 25 99.84 Very High Very High Very High
fluoxetine 1 99.52 Very High Very High Very High
Opioid 4 99.40 Very High Very High Very High
Desipramine 1 99.22 Very High Very High Very High
ischemia 80 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 25 99.84 Very High Very High Very High
Hypoxia 43 99.64 Very High Very High Very High
Hypothermia 8 99.54 Very High Very High Very High
Stress 114 99.24 Very High Very High Very High
Brain Hemorrhage 4 99.24 Very High Very High Very High
Injury 78 99.12 Very High Very High Very High
Brain Injury 68 97.16 Very High Very High Very High
Status Epilepticus 57 96.40 Very High Very High Very High
Thyroid Disease 6 95.04 Very High Very High Very High
Convulsion 50 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present electrophysiological study was undertaken to characterize the adrenoceptor mediating the suppressant effect of microiontophoretically applied norepinephrine (NE) on CA1 and CA3 dorsal hippocampus pyramidal neurons of the rat.
Regulation (effect) of CA1 in pyramidal neurons associated with pyramidal cell and hippocampus
1) Confidence 0.43 Published 1988 Journal Brain Res. Section Abstract Doc Link 2905622 Disease Relevance 0 Pain Relevance 0.64
Different responses of CA1 and CA3 regions to hypoxia in rat hippocampal slice.
Regulation (responses) of CA1 associated with hypoxia
2) Confidence 0.42 Published 1990 Journal J. Neurophysiol. Section Title Doc Link 2158521 Disease Relevance 1.01 Pain Relevance 0.12
Differential effects of pentobarbital and ether on the synaptic transmission of the hippocampal CA1 region in the rat.
Regulation (effects) of CA1
3) Confidence 0.41 Published 1981 Journal Electroencephalogr Clin Neurophysiol Section Title Doc Link 6163617 Disease Relevance 0 Pain Relevance 0
Although it remains to be determined whether such effects have a significant impact on the health of human and animal populations exposed to BPA, the current exposure limits clearly do not provide a wide margin of safety in terms of the acute estrogen-dependent regulation of CA1 PSSD.
Regulation (regulation) of CA1 PSSD in margin
4) Confidence 0.40 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0.15 Pain Relevance 0.05
Reasoning that previous electrophysiological studies may have overlooked voltage-dependent postsynaptic effects of the opioids in CA1, we reevaluated their role in CA1 HPNs using the rat hippocampal slice preparation for intracellular current- and voltage-clamp recording.
Regulation (role) of CA1 in HPNs associated with pyramidal cell and opioid
5) Confidence 0.39 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10515966 Disease Relevance 0 Pain Relevance 1.07
Intracellular injection of QX-314 (50-100 mM) did not change the phase-Vm or the amplitude-Vm relationships of CA1 PCs. 7.
Neg (not) Regulation (change) of CA1 in PCs associated with pyramidal cell
6) Confidence 0.36 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 8395591 Disease Relevance 0 Pain Relevance 0.40
Since it is well established that CA3 projections not only target CA1 but also project to the lateral septum bilaterally (Witter and Amaral, 2004), we assessed labeling in the latter structure as well in order to determine which intermediate pathway mediated the second order infection of CA3 neurons.
Regulation (target) of CA1 in neurons associated with infection
7) Confidence 0.35 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.17 Pain Relevance 0.08
by stimulation of the occipital cortex (A and B) or the CA1 region (C and D).
Regulation (stimulation) of CA1 in occipital cortex
8) Confidence 0.34 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.05 Pain Relevance 0.08
occipital cortex (during 2.5 minutes) or the ventral CA1 region (during 2.5 minutes),
Regulation (occipital cortex) of CA1 in ventral
9) Confidence 0.34 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0
We examined the neuroprotectant effect of tetrodotoxin on both cultured cerebellar neurons and on CA1 hippocampal neurons of gerbils exposed to brain ischemia.
Spec (examined) Regulation (effect) of CA1 in neurons associated with brain hemorrhage, tetrodotoxin and ischemia
10) Confidence 0.33 Published 1994 Journal Stroke Section Abstract Doc Link 7974592 Disease Relevance 0.27 Pain Relevance 0.39
7 nAChRs (Figure 1F–G), supporting the involvement of functional CA1 pyramidal ?
Regulation (involvement) of CA1
11) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.25
Responses in the CA1 region of the rat hippocampus to a noxious stimulus.
Regulation (Responses) of CA1 in hippocampus associated with pain and hippocampus
12) Confidence 0.28 Published 1992 Journal Exp. Neurol. Section Title Doc Link 1618285 Disease Relevance 0.43 Pain Relevance 0.41
In some cases, a lack of responses of CA1 pyramidal neurons to focal administration of 0.5–1 mM choline (Figures 2A and 2D) may have reflected an inability of whole-cell patch-clamp recordings to detect ?
Regulation (responses) of CA1 in pyramidal neurons associated with pyramidal cell
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.23
Finally, vertebral artery cauterization under halothane anesthesia caused an approximately 2 degrees C drop in brain temperature for 1 hour, but prevention of this hypothermia did not significantly affect CA1 damage.
Neg (not) Regulation (affect) of CA1 in brain associated with hypothermia, anesthesia and halothane
14) Confidence 0.27 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10413028 Disease Relevance 1.10 Pain Relevance 0.35
To detect specifically changes in the CA1 pyramidal neurons, we used the laser-capture microdissection technique that allows the precise isolation of the region of interest.
Regulation (changes) of CA1 in pyramidal neurons associated with pyramidal cell
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.40 Pain Relevance 0.12
Effects of morphine on CA1 versus dentate hippocampal field potentials following systemic administration in freely-moving rats.
Regulation (Effects) of CA1 associated with morphine
16) Confidence 0.24 Published 1982 Journal Neuropharmacology Section Title Doc Link 7088269 Disease Relevance 0 Pain Relevance 0.52
Metabolic genes such as Car 1 and 3 were down regulated, where as, Rdh2 and Rdh10 were up regulated (Table 5).
Regulation (regulated) of Car 1
17) Confidence 0.22 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.15 Pain Relevance 0.07
We reasoned that if BPA inhibits sexual differentiation of the rodent brain, there might also be significant interactions between estradiol and BPA with respect to the regulation of hippocampal CA1 PSSD.
Regulation (regulation) of CA1 PSSD in brain
18) Confidence 0.17 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.17
Our results indicate that BPA does indeed have potent effects on the regulation of CA1 PSSD.
Regulation (regulation) of CA1 PSSD
19) Confidence 0.17 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.24
Consistent with this hypothesis, in rat hippocampal organotypic cultures, regulation of NMDA receptors, which are critical components of the mechanisms responsible for estrogen regulation of CA1 dendritic spine density (Woolley and McEwen 1994), has been reported to be sensitive to nanomolar concentrations of either 17?
Regulation (regulation) of CA1 in spine associated with nmda receptor
20) Confidence 0.15 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox