INT120286

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 4.71
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc2)
Anatomy Link Frequency
livers 4
plasma 1
CAR 1
Abcc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 72 99.84 Very High Very High Very High
Bile 15 95.36 Very High Very High Very High
antidepressant 1 93.16 High High
Analgesic 1 92.48 High High
Opioid 1 92.04 High High
induced neuropathy 6 90.96 High High
Peripheral nerve injury 1 87.52 High High
vincristine 3 83.84 Quite High
Eae 2 83.04 Quite High
Central nervous system 1 81.20 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 3 100.00 Very High Very High Very High
Gallstones 6 99.44 Very High Very High Very High
Cancer 78 97.98 Very High Very High Very High
Stress 16 96.24 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 8 94.04 High High
Fatty Liver 12 93.68 High High
Neuropathic Pain 6 90.32 High High
Body Weight 6 90.20 High High
Skin Cancer 32 87.04 High High
Nervous System Injury 1 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APAP induced an increase in plasma membrane content of Mrp2 detected by western blotting, consistent with increased detection of the protein at the canalicular level by immunoflourescence microscopy.
Positive_regulation (increase) of Mrp2 in plasma associated with paracetamol
1) Confidence 0.70 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15276087 Disease Relevance 0.15 Pain Relevance 0.61
Real-time polymerase chain reaction studies indicated that up-regulation of Mrp2 and Mrp3 by SL and EE, respectively, was at the transcriptional level.
Positive_regulation (up-regulation) of Mrp2
2) Confidence 0.69 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.14 Pain Relevance 0.19
Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2.
Positive_regulation (up-regulation) of multidrug resistance-associated protein 2 associated with gallstones
3) Confidence 0.69 Published 2007 Journal Drug Metab. Dispos. Section Title Doc Link 17686906 Disease Relevance 0.20 Pain Relevance 0.14
Basal biliary excretion of oxidized glutathione, an endogenous Mrp2 substrate, was also increased by APAP, likely indicating increased hepatic synthesis as a result of APAP-induced oxidative stress followed by accelerated canalicular secretion mediated by Mrp2.
Spec (likely) Positive_regulation (increased) of Mrp2 associated with stress and paracetamol
4) Confidence 0.50 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15276087 Disease Relevance 0.17 Pain Relevance 0.81
To determine the functional impact of up-regulation of Mrp3 versus Mrp2, we measured the excretion of acetaminophen glucuronide (APAP-glu), a common substrate for both transporters, into bile and perfusate in the recirculating isolated perfused liver (IPL) model.
Positive_regulation (up-regulation) of Mrp2 in IPL associated with bile and paracetamol
5) Confidence 0.48 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16554369 Disease Relevance 0 Pain Relevance 0.44
Concerning cisplatin, which is also a strong neurotoxic drug but only an multidrug resistance protein 2 (MRP2) substrate, the same assumption could be suggested for MRP2 nervous function.
Positive_regulation (suggested) of MRP2
6) Confidence 0.47 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16859677 Disease Relevance 0.83 Pain Relevance 0.96
The EE+SL group showed increased levels of Mrp2 and Mrp3 to the same extent as that registered for the individual treatments.
Positive_regulation (increased) of Mrp2
7) Confidence 0.46 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.15 Pain Relevance 0.16
We demonstrate a more efficient hepatic synthesis and basolateral excretion of APAP-GLU followed by its urinary elimination in BDL group, the latter two processes consistent with up-regulation of liver Mrp3 and renal Mrp2.
Positive_regulation (up-regulation) of Mrp2 in liver associated with paracetamol
8) Confidence 0.41 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18096675 Disease Relevance 0.09 Pain Relevance 0.70
Recently, bilirubin was reported to be an endogenous activator of the CAR gene, which is in turn associated with the induction of bilirubin metabolising proteins, such as organic anion transporter SLC21A6, glutathione-S-transferase (GST), UGT1A1 and MRP2.
Positive_regulation (induction) of MRP2 in CAR
9) Confidence 0.25 Published 2004 Journal Nucl Recept Section Body Doc Link PMC517509 Disease Relevance 0 Pain Relevance 0.04
Despite high concentrations of the cytostatic drug and the exposition towards hyperthermic temperatures, only temporary effects on gene expression, that is, mrp1 (suppression) and mrp2 (induction) could be observed.
Positive_regulation (induction) of mrp2
10) Confidence 0.18 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.78 Pain Relevance 0
In single-tumor samples, a temporary suppression of mrp1 in groups I, II, and III was observed as well as a passing induction of mrp2 in groups II, III, and IV.
Positive_regulation (induction) of mrp2 associated with cancer
11) Confidence 0.16 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.41 Pain Relevance 0.03
In the livers of MCD rats, there were striking increases in both mRNA and protein levels of multidrug resistance-associated protein (Mrp) 3, Mrp4, and breast cancer resistance protein, as well as increased Mrp2 protein.
Positive_regulation (increases) of Mrp2 protein in livers associated with breast cancer
12) Confidence 0.10 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17640958 Disease Relevance 0.93 Pain Relevance 1.06
In the livers of MCD rats, there were striking increases in both mRNA and protein levels of multidrug resistance-associated protein (Mrp) 3, Mrp4, and breast cancer resistance protein, as well as increased Mrp2 protein.
Positive_regulation (increased) of Mrp2 protein in livers associated with breast cancer
13) Confidence 0.06 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17640958 Disease Relevance 0.87 Pain Relevance 1.05

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