INT120287

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Context Info
Confidence 0.24
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc2)
Anatomy Link Frequency
enterocyte 1
liver 1
Abcc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 11 100.00 Very High Very High Very High
cINOD 3 90.04 High High
diclofenac 1 80.20 Quite High
Bile 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Body Weight 1 96.20 Very High Very High Very High
Injury 6 93.92 High High
INFLAMMATION 1 79.24 Quite High
Diarrhoea 1 66.48 Quite High
Stress 2 63.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein.
Regulation (Effect) of resistance-associated protein 2 in liver associated with paracetamol
1) Confidence 0.24 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15276087 Disease Relevance 0.16 Pain Relevance 0.70
Observations from clinical and experimental studies have defined key events in the pathogenesis of these drugs, including roles for multidrug resistance-associated protein 2 (MRP2) and other transporters in biliary secretion and adduction of enterocyte proteins by reactive acyl glucuronide metabolites as a likely mechanism for intestinal injury.
Regulation (roles) of resistance-associated protein 2 in enterocyte associated with injury
2) Confidence 0.09 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16842856 Disease Relevance 0.65 Pain Relevance 0.36

General Comments

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