INT120288

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 1.30
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc2)
Anatomy Link Frequency
liver 6
Abcc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 12 100.00 Very High Very High Very High
Morphine 6 99.20 Very High Very High Very High
Bile 5 91.24 High High
ischemia 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gallstones 6 96.92 Very High Very High Very High
Body Weight 3 96.20 Very High Very High Very High
Skin Cancer 16 89.44 High High
Cancer 39 83.64 Quite High
Osteogenic Sarcomas 1 80.28 Quite High
Plasmacytoma 2 79.60 Quite High
Metastasis 4 66.64 Quite High
Stress 8 63.40 Quite High
Shock 10 50.00 Quite Low
Disease 1 33.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis.
Regulation (affects) of Gene_expression (expression) of MRP2 in liver associated with gallstones and morphine
1) Confidence 0.44 Published 2009 Journal J. Pharm. Pharmacol. Section Title Doc Link 19703370 Disease Relevance 0.10 Pain Relevance 0.33
Altered expression of MRP2, MRP3 and UGT2B1 in the liver affects the disposition of morphine and its glucuronide conjugate in a rat model of cholestasis.
Regulation (Altered) of Gene_expression (expression) of MRP2 in liver associated with gallstones and morphine
2) Confidence 0.44 Published 2009 Journal J. Pharm. Pharmacol. Section Title Doc Link 19703370 Disease Relevance 0.10 Pain Relevance 0.33
Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein.
Regulation (Effect) of Gene_expression (expression) of resistance-associated protein 2 in liver associated with paracetamol
3) Confidence 0.39 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15276087 Disease Relevance 0.16 Pain Relevance 0.70
Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls.
Regulation (affected) of Gene_expression (expression) of Mrp2
4) Confidence 0.27 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.15 Pain Relevance 0.16
Despite high concentrations of the cytostatic drug and the exposition towards hyperthermic temperatures, only temporary effects on gene expression, that is, mrp1 (suppression) and mrp2 (induction) could be observed.
Regulation (effects) of Gene_expression (expression) of mrp2
5) Confidence 0.16 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.80 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox