INT12029

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 143
Total Number 146
Disease Relevance 29.69
Pain Relevance 36.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
pyramidal neurons 31
neurons 13
interneurons 12
hippocampus 7
synapses 7
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 4455 100.00 Very High Very High Very High
Hippocampus 1071 100.00 Very High Very High Very High
depression 296 100.00 Very High Very High Very High
ASIC 216 100.00 Very High Very High Very High
amygdala 73 100.00 Very High Very High Very High
ischemia 1060 99.98 Very High Very High Very High
Glutamate receptor 34 99.98 Very High Very High Very High
GABAergic 273 99.74 Very High Very High Very High
nMDA receptor 97 99.48 Very High Very High Very High
long-term potentiation 807 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 296 100.00 Very High Very High Very High
Urological Neuroanatomy 38 100.00 Very High Very High Very High
Necrosis 24 100.00 Very High Very High Very High
Cv Unclassified Under Development 428 99.98 Very High Very High Very High
Aids-related Complex 16 99.88 Very High Very High Very High
Neurodegenerative Disease 78 99.80 Very High Very High Very High
Cv General 4 Under Development 609 99.72 Very High Very High Very High
Stress 308 99.70 Very High Very High Very High
Nociception 148 99.68 Very High Very High Very High
Infection 142 98.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On average, CA1 necrosis was less, and behavioral recovery time was shorter, in rats treated with PD117302 postocclusion as compared with vehicle-treated rats.
Gene_expression (necrosis) of CA1 associated with necrosis
1) Confidence 0.67 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 8044684 Disease Relevance 0.61 Pain Relevance 0.32
T-588 produced a slow and long-lasting depolarization of CA1 neurons with an increase in membrane resistance; this action showed close similarity to that of acetylcholine (ACh).
Gene_expression (produced) of CA1 in neurons
2) Confidence 0.66 Published 1999 Journal Brain Res. Section Abstract Doc Link 10411997 Disease Relevance 0.17 Pain Relevance 0.09
The effect of ether and sodium pentobarbital on the synaptic transmission of the hippocampal CA1 region was studied in chronically implanted rats.
Gene_expression (transmission) of CA1
3) Confidence 0.61 Published 1981 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 6163617 Disease Relevance 0 Pain Relevance 0
DISCUSSION: It is concluded that dependence on morphine enhances PTZ-induced plastic and epileptic changes in CA1 excitability.
Gene_expression (excitability) of CA1
4) Confidence 0.59 Published 2009 Journal Epilepsia Section Body Doc Link 19183220 Disease Relevance 0 Pain Relevance 0
In addition to these five genes, we have defined the “greater urea cycle” and also examined the expression of mRNA for nine additional enzymes that play a role in the disposal of nitrogen in the liver (glutamine synthetase, glutamine dehydrogenase, malate dehydrogenase, carbonic anhydrase, glutaminase, ornithine decarboxylase, tyrosine aminotransferase, aspartate aminotransferase and alanine aminotransferase), and two additional genes involved in transcriptional regulation of those genes; glucocorticoid receptor (GR) and CCAAT/enhancer binding protein (CEBP-?).
Spec (examined) Gene_expression (expression) of carbonic anhydrase in liver
5) Confidence 0.58 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.29 Pain Relevance 0.06
These results suggest a role of CA3 pyramidal neurons in the generation of CA1 theta via the activation of NMDA receptors of CA1 pyramidal neurons.
Gene_expression (generation) of CA1 in pyramidal neurons associated with nmda receptor and pyramidal cell
6) Confidence 0.58 Published 2002 Journal Hippocampus Section Abstract Doc Link 12201628 Disease Relevance 0 Pain Relevance 0.48
the occipital cortex gave rise to a short period (about 5 minutes) of depression

(or even irresponsiveness) of ipsilateral EC neurons to CA1 stimulation, both

Gene_expression (stimulation) of CA1 in occipital cortex associated with depression
7) Confidence 0.58 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.22 Pain Relevance 0.22
the CA1 region only potentiates the responses driven by the tetanized region confirms
Gene_expression (region) of CA1
8) Confidence 0.58 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.05 Pain Relevance 0.11
Here with both treatments, the l-CMRg in the claustrum, septal nucleus, amygdala, and ventral areas of CA1 and CA3 of the hippocampus remained at control values.
Gene_expression (claustrum) of CA1 in ventral associated with hippocampus and amygdala
9) Confidence 0.57 Published 1984 Journal Anesthesiology Section Abstract Doc Link 6703383 Disease Relevance 0.07 Pain Relevance 0.23
The expression of BDNF and PSD-95 in hippocampal CA1 were identified with RT-PCR.
Gene_expression (expression) of CA1
10) Confidence 0.57 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18630696 Disease Relevance 0.09 Pain Relevance 0
When maximal dentate activation was present bursts of population spikes were also recorded in CA3 and CA1.
Gene_expression (recorded) of CA1 in spikes
11) Confidence 0.56 Published 1994 Journal Epilepsy Res. Section Abstract Doc Link 8088253 Disease Relevance 0 Pain Relevance 0.03
Putative CA1 pyramidal neurons (n?
Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
12) Confidence 0.54 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889929 Disease Relevance 0.26 Pain Relevance 0.42
Ischemia produced CA1 hippocampal necrosis and prolonged suppression of responding under both schedule components.
Gene_expression (produced) of CA1 associated with necrosis and ischemia
13) Confidence 0.52 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 8044684 Disease Relevance 0.59 Pain Relevance 0.29
We infused NMDA into the dentate gyrus, CA3, CA2, CA1, and subiculum (Table 1) to produce excitotoxic lesions of the hippocampal formation.
Gene_expression (produce) of CA1 in dentate gyrus
14) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2674562 Disease Relevance 0 Pain Relevance 0.07
Substance P and other neuropeptides of the tachykinin family can powerfully excite CA1 hippocampal interneurons present in the CA1 region.
Gene_expression (present) of CA1 in interneurons associated with neuropeptide and substance p
15) Confidence 0.51 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12823471 Disease Relevance 0 Pain Relevance 0.34
positions of the stimulating electrodes in the occipital cortex and ventral CA1
Gene_expression (occipital cortex) of CA1 in ventral
16) Confidence 0.50 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0
more ventral CA1 regions innervate progressively more medial regions of the
Gene_expression (regions) of CA1 in ventral
17) Confidence 0.50 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0.11
the occipital neocortex or the ventral CA1 region in normal eutrophic animals,
Gene_expression (region) of CA1 in ventral
18) Confidence 0.50 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.09 Pain Relevance 0.18
EC field responses evoked from the occipital cortex or from the CA1 region (P > .05
Gene_expression (region) of CA1 in occipital cortex
19) Confidence 0.50 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0
medial EC of normal eutrophic rats can develop LTP in vivo to tetanization of both the occipital cortex and the CA1
Gene_expression (occipital cortex) of CA1 in occipital cortex associated with long-term potentiation
20) Confidence 0.50 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.25 Pain Relevance 0.13

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