INT120298

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 16
Disease Relevance 8.99
Pain Relevance 6.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
brain 4
amygdala 4
ventral 3
dorsal 1
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 564 99.42 Very High Very High Very High
long-term potentiation 352 99.38 Very High Very High Very High
Rostral ventromedial medulla 5 99.28 Very High Very High Very High
nMDA receptor 46 99.24 Very High Very High Very High
amygdala 273 98.04 Very High Very High Very High
local anesthetic 1 97.84 Very High Very High Very High
lidocaine 1 97.12 Very High Very High Very High
Inflammation 7 96.76 Very High Very High Very High
Morphine 10 96.68 Very High Very High Very High
depression 161 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 825 99.98 Very High Very High Very High
Targeted Disruption 281 99.48 Very High Very High Very High
INFLAMMATION 5 96.76 Very High Very High Very High
Depression 161 95.80 Very High Very High Very High
Injury 4 87.40 High High
Pain 9 86.04 High High
Hyperalgesia 1 75.00 Quite High
Anxiety Disorder 84 50.00 Quite Low
Cognitive Disorder 33 42.96 Quite Low
Affective Disorder 22 36.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, since PKA and CaMKII act in parallel in controlling synaptic incorporation of GluR1 [39], reduced phosphorylation of GluR1p845 may affect activity-dependent AMPA receptor trafficking.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of GluR1
1) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.94 Pain Relevance 0.59
Recently, it has been reported that phosphorylation of GluR1p845 in the neostriatum was reduced in neurabin KO mice [20].
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of GluR1 associated with targeted disruption
2) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.55 Pain Relevance 0.06
The upregulated GluR1 phosphorylation was blocked by pretreatment, but not by post-treatment, with the local anesthetic, lidocaine, at the site of inflammation.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of GluR1 associated with inflammation, lidocaine and local anesthetic
3) Confidence 0.53 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15276247 Disease Relevance 0.61 Pain Relevance 0.95
Moreover, the contrasting results we obtained for the GluA1 phosphorylation in the DH and the VH, which were manifested as a decrease of Ser831-GluA1 phosphorylation and an increase of Ser845-GluA1 phosphorylation, respectively, provide support for the recent hypothesis that stress differentially regulates ventral and dorsal routing within the hippocampus [8], [25].
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of GluA1 in ventral associated with stress and hippocampus
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.60 Pain Relevance 0.63
The present methodology targeted a more-specific brain region and we observed that exposure to elevated platform stress decreased the phosphorylation of Ser831 on the GluA1 subunit in the mPFC.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of GluA1 in brain associated with stress
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.82 Pain Relevance 0.11
After stress, the phosphorylation of Ser831-GluA1 was markedly decreased in the mPFC and DH, whereas the phosphorylation of Ser845-GluA1 was increased in the amygdala and VH.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress, hippocampus and amygdala
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2999558 Disease Relevance 0.60 Pain Relevance 0.68
Here we have reported that stress induces a decrease in Ser831-GluA1 phosphorylation.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of GluA1 associated with stress
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.64 Pain Relevance 0.11
First, the reduced phosphorylation of GluR1p845 in the neurabin KO may affect activity-dependent AMPA receptor contribution to LTP.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of GluR1 associated with targeted disruption and long-term potentiation
8) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.61 Pain Relevance 0.23
We have previously reported that elevated platform stress does not lead to a general modulation of GluA1 phosphorylation in brain tissue sampled from the entire frontal cortices [35].
Negative_regulation (modulation) of Phosphorylation (phosphorylation) of GluA1 in brain associated with stress
9) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.67 Pain Relevance 0.07
Acute stress exposure decreases phosphorylation of GluA1 in the mPFC and DH
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of GluA1 associated with stress and hippocampus
10) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.38 Pain Relevance 0.13
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Negative_regulation (level) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress and amygdala
11) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.46 Pain Relevance 0.48
The phosphorylation levels of GluR1 and NR1 subunits decreased in parallel with those of phospho-Thr-34 DARPP-32, supporting the hypothesis that morphine challenge elicited a decrease in PKA activity in morphine-sensitized rats.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of GluR1 associated with morphine
12) Confidence 0.34 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.06
In light of these previous findings, our present results suggest that the mechanism by which acute stress disrupts LTP in these regions involves the reduction of Ser831-GluA1 phosphorylation.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of GluA1 associated with stress and long-term potentiation
13) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.55 Pain Relevance 0.58
Previous work from hippocampal slice physiology indicates that NMDAR blockade can cause a similar decrease in Ser831-GluA1 phosphorylation [47].
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of GluA1
14) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.55 Pain Relevance 0.11
Thirty minutes after the end of stress, a significant decrease in the phosphorylation level of Ser831-GluA1 was found in mPFC and DH of stressed animals compared to controls (t (19)?
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of GluA1 associated with stress and hippocampus
15) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.41 Pain Relevance 0.26
Moreover, the contrasting results we obtained for the GluA1 phosphorylation in the DH and the VH, which were manifested as a decrease of Ser831-GluA1 phosphorylation and an increase of Ser845-GluA1 phosphorylation, respectively, provide support for the recent hypothesis that stress differentially regulates ventral and dorsal routing within the hippocampus [8], [25].
Negative_regulation (decrease) of in dorsal Phosphorylation (phosphorylation) of GluA1 in ventral associated with stress and hippocampus
16) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.60 Pain Relevance 0.63

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