INT12030

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 19
Disease Relevance 3.98
Pain Relevance 5.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
pyramidal neurons 5
dendrites 4
neurons 4
synapses 4
cortex 2
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 628 100.00 Very High Very High Very High
Hippocampus 96 100.00 Very High Very High Very High
depression 34 100.00 Very High Very High Very High
GABAergic 25 100.00 Very High Very High Very High
ischemia 127 99.64 Very High Very High Very High
Nucleus accumbens 146 99.44 Very High Very High Very High
nMDA receptor antagonist 1 98.64 Very High Very High Very High
bDMF 24 98.00 Very High Very High Very High
nMDA receptor 4 95.08 Very High Very High Very High
adenocard 163 93.04 High High
Disease Link Frequency Relevance Heat
Depression 34 100.00 Very High Very High Very High
Cv Unclassified Under Development 59 99.64 Very High Very High Very High
Cognitive Disorder 86 91.04 High High
Apoptosis 16 90.44 High High
Neurodegenerative Disease 14 80.24 Quite High
Cv General 4 Under Development 64 78.00 Quite High
Death 15 69.16 Quite High
Targeted Disruption 12 55.44 Quite High
Appetite Loss 30 50.00 Quite Low
Brain Hemorrhage 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T-588 produced a slow and long-lasting depolarization of CA1 neurons with an increase in membrane resistance; this action showed close similarity to that of acetylcholine (ACh).
Positive_regulation (increase) of Gene_expression (produced) of CA1 in neurons
1) Confidence 0.50 Published 1999 Journal Brain Res. Section Abstract Doc Link 10411997 Disease Relevance 0.17 Pain Relevance 0.09
DISCUSSION: It is concluded that dependence on morphine enhances PTZ-induced plastic and epileptic changes in CA1 excitability.
Positive_regulation (induced) of Gene_expression (excitability) of CA1
2) Confidence 0.44 Published 2009 Journal Epilepsia Section Body Doc Link 19183220 Disease Relevance 0 Pain Relevance 0
DISCUSSION: It is concluded that dependence on morphine enhances PTZ-induced plastic and epileptic changes in CA1 excitability.
Positive_regulation (enhances) of Gene_expression (excitability) of CA1
3) Confidence 0.44 Published 2009 Journal Epilepsia Section Body Doc Link 19183220 Disease Relevance 0 Pain Relevance 0
the CA1 area, did not differ from those of normal eutrophic rats (unpaired
Neg (not) Positive_regulation (differ) of Gene_expression (area) of CA1
4) Confidence 0.38 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0.03
more ventral CA1 regions innervate progressively more medial regions of the
Positive_regulation (innervate) of Gene_expression (regions) of CA1 in ventral
5) Confidence 0.38 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0.11
In the presence of PNU-120596, physiological concentrations of choline were found to elicit a weak persistent activation of CA1 pyramidal ?
Positive_regulation (activation) of Gene_expression (pyramidal) of CA1
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0.14 Pain Relevance 0.35
This suggested that noxious stimulus-induced CA1 synaptic depression is mediated at the apical dendritic region, perhaps postsynaptically at the dendrites and/or presynaptically on CA3 afferent terminals.
Positive_regulation (mediated) of Gene_expression (depression) of CA1 in dendrites associated with depression
7) Confidence 0.31 Published 1992 Journal Exp. Neurol. Section Abstract Doc Link 1618285 Disease Relevance 0.80 Pain Relevance 0.47
This suggested that noxious stimulus-induced CA1 synaptic depression is mediated at the apical dendritic region, perhaps postsynaptically at the dendrites and/or presynaptically on CA3 afferent terminals.
Positive_regulation (stimulus-induced) of Gene_expression (depression) of CA1 in dendrites associated with depression
8) Confidence 0.31 Published 1992 Journal Exp. Neurol. Section Abstract Doc Link 1618285 Disease Relevance 0.80 Pain Relevance 0.47
10 µM) are effective in eliciting a weak but persistent activation of functional hippocampal CA1 pyramidal ?
Positive_regulation (activation) of Gene_expression (pyramidal) of CA1
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.21
CA1 pyramidal neurons receive inhibitory GABAergic inputs from CA1 interneurons that express high densities of ?
Positive_regulation (receive) of in pyramidal neurons Gene_expression (interneurons) of CA1 in interneurons associated with gabaergic and pyramidal cell
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.34
7-containing nAChRs in CA1 pyramidal neurons may not be necessary for triggering important cellular and network functions, especially if activation of ?
Neg (not) Positive_regulation (necessary) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
11) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.13
CA1 pyramidal neurons receive inhibitory GABAergic inputs from CA1 interneurons that express high densities of ?
Positive_regulation (receive) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with gabaergic and pyramidal cell
12) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.33
That the rapid actions of estradiol on CA1 PSSD involve nonclassical ER systems is also suggested by recent data from this laboratory demonstrating that short-term induction of CA1 spine synapses requires relatively high circulating 17?
Positive_regulation (induction) of Gene_expression (synapses) of CA1 in synapses
13) Confidence 0.28 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.04
Global ischemia induced a marked increase in the incidence of TUNEL—positive CA1 neurons (Figures 2c, 2g).
Positive_regulation (increase) of Gene_expression (neurons) of CA1 in neurons associated with ischemia
14) Confidence 0.27 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.79 Pain Relevance 0.52
Group 1 had increased bcl-2 and bax protein expression in hippocampal CA1 region at 6 h after CPB (bcl-2, 0.18 +/- 0.05 versus 0.09 +/- 0.01; P = 0.02; bax, 0.20 +/- 0.06 versus 0.04 +/- 0.02; P = 0.01; Group 1 versus Group 2, respectively).
Positive_regulation (increased) of Gene_expression (expression) of CA1
15) Confidence 0.20 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.29 Pain Relevance 0.22
Group 1 had increased bcl-2 and bax protein expression in hippocampal CA1 region at 6 h after CPB (bcl-2, 0.18 +/- 0.05 versus 0.09 +/- 0.01; P = 0.02; bax, 0.20 +/- 0.06 versus 0.04 +/- 0.02; P = 0.01; Group 1 versus Group 2, respectively).
Positive_regulation (had) of Gene_expression (expression) of CA1
16) Confidence 0.20 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.29 Pain Relevance 0.22
The activation of CREB in the CA1 region by EDC following reperfusion was also observed at multiple time points (10min, 3h, 6h and 24h).
Positive_regulation (activation) of Gene_expression (region) of CA1
17) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.70 Pain Relevance 0.40
To label Acb neurons, electrophysiological responses of Acb cells evoked by electrical stimulation of either the ventral hippocampus (in particular the CA1 region) or the medial prefrontal cortex (PFC) were used as a guide for stereotaxic placement of recordings within the Acb shell or core, respectively.
Positive_regulation (stimulation) of Gene_expression (region) of CA1 in cortex associated with nucleus accumbens and hippocampus
18) Confidence 0.12 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.67
This currently remains unknown but would be relatively easy to answer by stimulating CA1 synapses with trains, with and without an NMDA receptor antagonist.
Positive_regulation (stimulating) of Gene_expression (synapses) of CA1 in synapses associated with nmda receptor antagonist
19) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701281 Disease Relevance 0 Pain Relevance 0.67

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