INT12031

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 44
Total Number 44
Disease Relevance 20.46
Pain Relevance 19.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
dentate gyrus 6
hippocampus 6
spikes 3
pyramidal cell 3
neurons 3
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 258 100.00 Very High Very High Very High
Pyramidal cell 173 100.00 Very High Very High Very High
long-term potentiation 92 100.00 Very High Very High Very High
depression 62 100.00 Very High Very High Very High
opioid receptor 6 100.00 Very High Very High Very High
fortral 2 100.00 Very High Very High Very High
ischemia 98 99.88 Very High Very High Very High
Morphine 38 99.70 Very High Very High Very High
Gabapentin 10 99.70 Very High Very High Very High
Action potential 13 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 142 100.00 Very High Very High Very High
Depression 62 100.00 Very High Very High Very High
Hypoxia 45 100.00 Very High Very High Very High
Fever 37 99.90 Very High Very High Very High
Cv General 4 Under Development 56 99.88 Very High Very High Very High
Convulsion 85 99.70 Very High Very High Very High
Cv Unclassified Under Development 40 99.62 Very High Very High Very High
Status Epilepticus 57 99.52 Very High Very High Very High
Kidney Stones 1 99.52 Very High Very High Very High
Hypothermia 9 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the adult rat, a decrease in CA1 inhibition requires a higher degree of hyperthermia, and hippocampal seizure generation is opposed by an increase in dentate gyrus inhibition.
Negative_regulation (inhibition) of CA1 in dentate gyrus associated with convulsion, hippocampus and fever
1) Confidence 0.59 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12205644 Disease Relevance 0.97 Pain Relevance 0.50
Gabapentin also caused a reduction of inhibition in the CA1 region, indicating that its effect is not specific for the dentate gyrus.
Negative_regulation (reduction) of CA1 in dentate gyrus associated with gabapentin
2) Confidence 0.57 Published 1999 Journal Epilepsy Res. Section Abstract Doc Link 10094428 Disease Relevance 0 Pain Relevance 1.07
However, slices from morphine-dependent rats maintained in ACSF with morphine significantly attenuated hippocampal CA1 LTP.
Negative_regulation (attenuated) of CA1 associated with long-term potentiation and morphine
3) Confidence 0.57 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591126 Disease Relevance 0 Pain Relevance 1.81
We suggest that hyperthermia contributes to seizure susceptibility in the immature hippocampus by decreasing CA1 inhibition.
Negative_regulation (inhibition) of CA1 in CA1 associated with convulsion, hippocampus and fever
4) Confidence 0.51 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12205644 Disease Relevance 0.93 Pain Relevance 0.51
complete loss of the CA1-evoked EC response after tetanizing the OC could be
Negative_regulation (loss) of CA1
5) Confidence 0.44 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0.33 Pain Relevance 0.23
This dose, administered as a pretreatment, also truncated CA1 pyramidal cell suppression or excitation to a formalin injection.
Negative_regulation (suppression) of CA1 in pyramidal cell associated with pyramidal cell
6) Confidence 0.43 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051217 Disease Relevance 0.07 Pain Relevance 0.69
Persistent block of CA1 synaptic function by prolonged hypoxia.
Negative_regulation (block) of CA1 associated with hypoxia
7) Confidence 0.43 Published 1999 Journal Neuroscience Section Title Doc Link 10218777 Disease Relevance 0.64 Pain Relevance 0.14
However, PTZ-induced multiple population spikes (epileptiform activity) in CA1 was not blocked by naloxone.
Negative_regulation (blocked) of CA1 in spikes
8) Confidence 0.43 Published 2009 Journal Epilepsia Section Body Doc Link 19183220 Disease Relevance 0 Pain Relevance 0
T-588 produced a slow and long-lasting depolarization of CA1 neurons with an increase in membrane resistance; this action showed close similarity to that of acetylcholine (ACh).
Negative_regulation (depolarization) of CA1 in neurons
9) Confidence 0.42 Published 1999 Journal Brain Res. Section Abstract Doc Link 10411997 Disease Relevance 0.16 Pain Relevance 0.09
Other serious adverse events include rare narrow angle-closure glaucoma early in treatment, hyperchloremic acidosis in >10% of patients, nephrolithiasis at a rate of 1% due to carbonic anhydrase inhibition, and rare oligohydrosis, which can result in fatal hyperthermia, more frequently in younger age groups at higher doses (Ziad et al 2005).
Negative_regulation (inhibition) of carbonic anhydrase associated with acidosis, glaucoma, fever and kidney stones
10) Confidence 0.42 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646645 Disease Relevance 1.24 Pain Relevance 0.26
In this study the effect of transient inhibition of the CA1 region of the dorsal hippocampus by lidocaine on amygdala kindling rate and amygdaloid kindled seizures was investigated.
Negative_regulation (inhibition) of CA1 in amygdala associated with convulsion, hippocampus, amygdala and lidocaine
11) Confidence 0.41 Published 2002 Journal Brain Res. Section Abstract Doc Link 12414105 Disease Relevance 0.17 Pain Relevance 0.36
JO 1784 (3 mg/kg subcutaneously) successfully attenuated this loss of [3H] (+)-pentazocine binding sites in the hippocampus (CA1, CA3 and CA4 regions) and in the substantia innominata.
Negative_regulation (loss) of CA1 in hippocampus associated with fortral and hippocampus
12) Confidence 0.41 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8737963 Disease Relevance 0.07 Pain Relevance 0.37
In the immature rat, paired-pulse inhibition was unchanged in the dentate gyrus but decreased in CA1 during moderate hyperthermia (p < 0.05).
Negative_regulation (decreased) of CA1 in CA1 associated with hippocampus and fever
13) Confidence 0.38 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12205644 Disease Relevance 0.96 Pain Relevance 0.52
In the adult rat, paired-pulse inhibition was increased in the dentate gyrus during moderate and severe hyperthermia but decreased in CA1 during severe hyperthermia (all p values < 0.05).
Negative_regulation (decreased) of CA1 in dentate gyrus associated with hippocampus and fever
14) Confidence 0.38 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12205644 Disease Relevance 0.95 Pain Relevance 0.53
The above data are consistent with the notion that septohippocampal inputs are involved in noxious stimulus-induced CA1 pyramidal cell suppression.
Negative_regulation (suppression) of CA1 in pyramidal cell associated with pyramidal cell
15) Confidence 0.38 Published 1997 Journal Neuroscience Section Abstract Doc Link 9070747 Disease Relevance 0.33 Pain Relevance 0.59
Untreated normothermic ischemia resulted in total CA1 cell loss (99%), whereas delayed hypothermia treatment reduced neuronal loss to 14% at a 28-day survival.
Negative_regulation (loss) of CA1 in neuronal associated with hypothermia and ischemia
16) Confidence 0.38 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10413028 Disease Relevance 1.14 Pain Relevance 0.33
Morphine reversed formalin-induced CA1 pyramidal cell suppression via an effect on septohippocampal neural processing.
Negative_regulation (suppression) of CA1 in pyramidal cell associated with pyramidal cell and morphine
17) Confidence 0.38 Published 1999 Journal Neuroscience Section Title Doc Link 10051217 Disease Relevance 0.09 Pain Relevance 0.96
In the whole-cell voltage-clamp study, T-588 produced a reversible block of the outward potassium current in CA1 neurons.
Negative_regulation (block) of CA1 in neurons
18) Confidence 0.37 Published 1999 Journal Brain Res. Section Abstract Doc Link 10411997 Disease Relevance 0.14 Pain Relevance 0.09
In normal (3.5 mM) [K+]o, synaptically driven population spikes in CA1 were only reduced in amplitude by hypoxia; hypoxia did not induce seizures in 3.5 mM [K+]o.
Negative_regulation (reduced) of CA1 in spikes associated with convulsion and hypoxia
19) Confidence 0.35 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2158521 Disease Relevance 1.07 Pain Relevance 0.13
The probability of seizure generation in CA1 was increased with increasing duration of hypoxia and was greatly reduced by lowering the bath temperature a few degrees. 3.
Negative_regulation (reduced) of CA1 associated with convulsion and hypoxia
20) Confidence 0.35 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2158521 Disease Relevance 1.52 Pain Relevance 0.22

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