INT12032

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Context Info
Confidence 0.34
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 24
Disease Relevance 7.23
Pain Relevance 7.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
pyramidal neurons 22
horn 2
cell body 2
synapses 2
hippocampus CA1 2
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 917 100.00 Very High Very High Very High
Hippocampus 212 100.00 Very High Very High Very High
depression 28 100.00 Very High Very High Very High
ischemia 353 99.88 Very High Very High Very High
long-term potentiation 42 99.66 Very High Very High Very High
Spinal cord 7 97.04 Very High Very High Very High
Dorsal horn 1 96.48 Very High Very High Very High
medulla 3 96.40 Very High Very High Very High
cerebral cortex 10 95.44 Very High Very High Very High
Central nervous system 5 94.24 High High
Disease Link Frequency Relevance Heat
Stress 107 100.00 Very High Very High Very High
Depression 28 100.00 Very High Very High Very High
Cv General 4 Under Development 229 99.88 Very High Very High Very High
Death 78 98.12 Very High Very High Very High
Cv Unclassified Under Development 120 96.20 Very High Very High Very High
Cognitive Disorder 179 93.84 High High
Epilepsy 25 90.80 High High
Morphine Dependence 4 88.04 High High
Neuropathic Pain 6 84.92 Quite High
Injury 18 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Putative CA1 pyramidal neurons (n?
Negative_regulation (Putative) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
1) Confidence 0.34 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889929 Disease Relevance 0.26 Pain Relevance 0.42
CONCLUSION: The expression of BDNF and PSD-95 in hippocampal CA1 decreases in morphine-depended rats withdrawn for 1 week.
Negative_regulation (decreases) of Gene_expression (expression) of CA1
2) Confidence 0.31 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18630696 Disease Relevance 0.07 Pain Relevance 0
Furthermore, atropine sulfate (40 mg/kg ip), which prevented the depression of the CA1 PS, also blocked the depression of dfEPSP when iontophoresed at the apical dendritic recording site.
Negative_regulation (prevented) of Gene_expression (depression) of CA1 associated with depression
3) Confidence 0.31 Published 1992 Journal Exp. Neurol. Section Abstract Doc Link 1618285 Disease Relevance 0.82 Pain Relevance 0.51
However, iontophoretic atropine at the cell body recording site did not prevent the depression of the CA1 PS.
Negative_regulation (prevent) of Gene_expression (depression) of CA1 in cell body associated with depression
4) Confidence 0.31 Published 1992 Journal Exp. Neurol. Section Abstract Doc Link 1618285 Disease Relevance 0.70 Pain Relevance 0.43
These experiments revealed that in the presence of PNU-120596 and 10 ┬ÁM choline, low densities of expression of CA1 pyramidal ?
Negative_regulation (densities) of Gene_expression (pyramidal) of CA1
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0.06 Pain Relevance 0.21
RESULTS: The expression of BDNF and PSD-95 in hippocampal CA1 decreased in the withdrawn group with morphine dependence for 1 week as compared with that in normal saline (NS) group (P < 0.01), and it increased in the withdrawn group with morphine dependence for 2 weeks as compared with that in morphine-dependent group for 1 week (P < 0.05) but still decreased as compared with that in NS group (P < 0.01), and it decreased in the withdrawn group with morphine dependence for 4 weeks as compared with the other three groups (P < 0.01).
Negative_regulation (decreased) of Gene_expression (expression) of CA1
6) Confidence 0.27 Published 2008 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18630696 Disease Relevance 0.09 Pain Relevance 0
7* nAChRs in CA1 pyramidal neurons and CA1 interneurons
Negative_regulation (nAChRs) of Gene_expression (interneurons) of CA1 in pyramidal neurons associated with pyramidal cell
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.30
7* nAChRs in hippocampal CA1 pyramidal neurons
Negative_regulation (hippocampal) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.32
7* nAChR-mediated currents in hippocampal CA1 pyramidal neurons in slices rather than a lack of expression of functional ?
Negative_regulation (lack) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
9) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.27
7* nAChRs [43], [56], especially in hippocampal CA1 pyramidal neurons where expression of ?
Negative_regulation (hippocampal) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.13
7* nAChRs in CA1 pyramidal neurons and CA1 interneurons
Negative_regulation (nAChRs) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.30
Although hippocampal CA1 pyramidal neurons express functional ?
Negative_regulation (hippocampal) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.19
7* nAChRs in CA1 pyramidal neurons comprises of ?
Negative_regulation (nAChRs) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
13) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.24
7* nAChR-mediated currents in hippocampal CA1 pyramidal neurons in slices rather than a lack of expression of functional ?
Negative_regulation (hippocampal) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.27
In situ hybridization showed a high level of RSEP1 expression in the CA1, CA3 and dentate gyrus regions of the hippocampus and the small sensory neurons in the dorsal horn, as well as the large neurons in the ventral horn of the spinal cord.
Negative_regulation (level) of Gene_expression (expression) of CA1 in horn associated with dorsal horn, hippocampus and spinal cord
15) Confidence 0.24 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16176350 Disease Relevance 0.78 Pain Relevance 1.14
Effects of SKF83959 on somatic excitability of hippocampal CA1 pyramidal neurons
Negative_regulation (hippocampal) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
16) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948503 Disease Relevance 0 Pain Relevance 0.17
SKF83959 enhanced Ih current in hippocampal CA1 pyramidal neurons
Negative_regulation (hippocampal) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
17) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948503 Disease Relevance 0 Pain Relevance 0.09
Inhibition of Rac GTPase activation attenuates induction of oxidative stress damage in the hippocampus CA1 after GCI
Negative_regulation (Inhibition) of Gene_expression (hippocampus) of CA1 in hippocampus CA1 associated with stress, ischemia and hippocampus
18) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.32 Pain Relevance 0.46
production in the hippocampal CA1 region following GCI
Negative_regulation (hippocampal) of Gene_expression (region) of CA1 associated with ischemia
19) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.47 Pain Relevance 0.24
production in the rat hippocampal CA1 region following GCI
Negative_regulation (hippocampal) of Gene_expression (region) of CA1 associated with ischemia
20) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.67 Pain Relevance 0.24

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