INT120320

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.58
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Anatomy Link Frequency
neuronal 2
cortex 2
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 2 100.00 Very High Very High Very High
nMDA receptor 6 91.68 High High
Thalamus 4 87.92 High High
cytokine 9 25.32 Quite Low
Pain 2 25.00 Low Low
nociceptor 1 25.00 Low Low
Inflammation 16 21.48 Low Low
Potency 4 15.76 Low Low
Dopamine 7 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 4 98.88 Very High Very High Very High
Infection 29 95.80 Very High Very High Very High
Nociception 6 49.12 Quite Low
African Trypanosomiasis 13 36.80 Quite Low
INFLAMMATION 17 21.48 Low Low
Disease 15 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Parasitemia 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the expression of AVP heteronuclear (hn) RNA and neuronal nitric oxide synthase (nNOS) mRNA was also examined in the PVN of a CP-induced cystitis model.
Spec (examined) Positive_regulation (examined) of Spec (examined) Transcription (expression) of nNOS in neuronal associated with cystitis and neuronal nitric oxide synthase
1) Confidence 0.46 Published 2004 Journal Brain Res. Section Abstract Doc Link 15276878 Disease Relevance 0.26 Pain Relevance 0.05
CONCLUSION: Our preliminary data show that N2O induced a selective increase in nNOS and p53 transcription.
Positive_regulation (increase) of Transcription (transcription) of nNOS
2) Confidence 0.40 Published 2010 Journal Minerva Anestesiol Section Body Doc Link 20473255 Disease Relevance 0 Pain Relevance 0
Taking the nNOS molecules to exist in a 7 × 7 array and the extreme case of all of them being simultaneously active, and generating NO at the highest rate achievable from measurements of the activity of purified nNOS after adjusting for temperature (20 s?
Neg (NO) Positive_regulation (generating) of Transcription (activity) of nNOS
3) Confidence 0.36 Published 2009 Journal Nitric Oxide Section Body Doc Link PMC2779337 Disease Relevance 0 Pain Relevance 0.20
This view is further reinforced by the facts that in our experiments: (i) no significant variation was noticed in nNOS activity/protein and mRNA expression (data not shown); (ii) a specific iNOS inhibitor was capable of reducing the increase in NO production measured in the cortex of mice infected with T. b. brucei (data previously reported from our team [31]).
Positive_regulation (noticed) of Transcription (expression) of nNOS in cortex
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.31 Pain Relevance 0.04

General Comments

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