INT12033

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Context Info
Confidence 0.48
First Reported 1980
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.04
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
follicle 1
gonadal 1
pituitary 1
theca cell 1
pineal gland 1
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 7 99.98 Very High Very High Very High
withdrawal 34 99.28 Very High Very High Very High
Opioid 14 99.26 Very High Very High Very High
Dopamine 1 99.08 Very High Very High Very High
antagonist 60 99.04 Very High Very High Very High
agonist 49 98.74 Very High Very High Very High
opiate 3 98.58 Very High Very High Very High
Fibrositis 77 98.40 Very High Very High Very High
Catecholamine 1 98.30 Very High Very High Very High
tolerance 3 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 67 99.44 Very High Very High Very High
Fibromyalgia 77 98.40 Very High Very High Very High
Hypogonadotropic Hypogonadism 74 98.16 Very High Very High Very High
Ovarian Hyperstimulation Syndrome 11 98.16 Very High Very High Very High
Stress 27 97.66 Very High Very High Very High
Endocrine Disease 1 96.44 Very High Very High Very High
Depression 46 95.76 Very High Very High Very High
Galactorrhea 38 92.88 High High
Alcohol Addiction 3 90.60 High High
Endometriosis (extended) 115 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest the development of tolerance and supersensitivity to opiate agonist and antagonist effects on pituitary-gonadal hormones involves interaction between the direct effects of these drugs on LH followed by steroid feedback effects of T on gonadotrophin secretory activity.
LH Binding (interaction) of in gonadal associated with antagonist, agonist, tolerance and opiate
1) Confidence 0.48 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400959 Disease Relevance 0.22 Pain Relevance 0.41
As determined by time-series analysis, the cross-correlations between the LH/E2 and LH/P data series remained unaltered by opioid blockade.
LH Binding (cross-correlations) of
2) Confidence 0.37 Published 1998 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 9861326 Disease Relevance 0 Pain Relevance 0
As determined by time-series analysis, the cross-correlations between the LH/E2 and LH/P data series remained unaltered by opioid blockade.
LH Binding (cross-correlations) of
3) Confidence 0.37 Published 1998 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 9861326 Disease Relevance 0 Pain Relevance 0
The pineal gland-opioid system relation: melatonin-naloxone interactions in regulating GH and LH releases in man.
LH Binding (interactions) of in pineal gland associated with narcan and opioid
4) Confidence 0.36 Published 1988 Journal J. Endocrinol. Invest. Section Title Doc Link 3361078 Disease Relevance 0 Pain Relevance 0.76
We examined concentrations of follicle-stimulating hormone, luteinizing hormone (LH), estradiol, progesterone, prolactin, and cortisol.
LH Spec (examined) Binding (concentrations) of in follicle
5) Confidence 0.27 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC416440 Disease Relevance 1.52 Pain Relevance 0.28
However when we sub grouped our study population by serum LH levels similar to the above studies a statistical difference was found in cycles with basal serum LH ?
serum LH Binding (cycles) of
6) Confidence 0.26 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1947995 Disease Relevance 0.07 Pain Relevance 0.04
Both LH and hCG are heterodimers of noncovalently bound ?
LH Binding (bound) of
7) Confidence 0.24 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.58 Pain Relevance 0
Stress hormones such as catecholamines (adrenalin, nonadrenaline and dopamine) and the hypothalamic-pituitary-adrenal axis interact with hormones which are responsible for normal ovulatory cycles: i.e., gonadotropin releasing hormone (GnRH), prolactin, LH and FSH.
LH Binding (interact) of in pituitary associated with stress, dopamine and catecholamine
8) Confidence 0.23 Published 1992 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 1618356 Disease Relevance 1.39 Pain Relevance 0.20
It is also associated with low or low-normal FSH and LH levels.
LH Binding (associated) of
9) Confidence 0.17 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 1.82 Pain Relevance 0.05
At the completion of the urine collection, participants had blood drawn for calcium, phosphorus, parathyroid hormone (PTH), parathyroid related protein (PTH-rP), 1,25-(OH)2 vitamin D, albumin, bone specific alkaline phosphatase, estradiol, luteinizing hormone (LH) and follicle stimulating hormone (FSH).
LH Binding (drawn) of in urine
10) Confidence 0.12 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.44 Pain Relevance 0
While LH replacement typically prevented the decline induced by Antide, progestin replacement with R5020 was less effective in preventing TRL’s effects, except in some instances (e.g.
LH Binding (replacement) of associated with withdrawal
11) Confidence 0.12 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2647108 Disease Relevance 0 Pain Relevance 0.20
Thus, LH regulates and integrates both granulosa and theca cell function during late preovulatory development.
LH Binding (integrates) of in theca cell
12) Confidence 0.11 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.05 Pain Relevance 0.10
LH supplementation
LH Binding (supplementation) of
13) Confidence 0.11 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.14 Pain Relevance 0.13
Commercial kits for radioimmunoassay were used to determine the serum concentrations of testosterone (Medgenics Diagnostics, Fleurus, Belgium); commercial kits for immuradiometric assays were used for determinations of LH and FSH (Medgenics Diagnostics).
LH Binding (determinations) of
14) Confidence 0.10 Published 2006 Journal BMC Urol Section Body Doc Link PMC1444919 Disease Relevance 0.21 Pain Relevance 0
Recombinant LH
LH Binding (Recombinant) of
15) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.29 Pain Relevance 0
Hormonal assay: FSH, LH, Testosterone, TSH and Prolactin (for male with abnormal seminal analysis and suspected endocrine disorder)
LH Binding (assay) of associated with endocrine disease
16) Confidence 0.05 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2844387 Disease Relevance 1.30 Pain Relevance 0.13

General Comments

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