INT120331

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.15
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Napa) vesicle-mediated transport (Napa)
Anatomy Link Frequency
Paw 1
hearts 1
hippocampus 1
Napa (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 24 98.56 Very High Very High Very High
withdrawal 1 97.56 Very High Very High Very High
Hippocampus 2 96.72 Very High Very High Very High
Morphine 7 95.68 Very High Very High Very High
adenocard 22 92.00 High High
ischemia 27 90.36 High High
Glutamate 21 86.00 High High
opiate 2 85.36 High High
analgesia 1 85.20 High High
Thermal hyperalgesia 5 82.52 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 18 99.86 Very High Very High Very High
Injury 28 96.76 Very High Very High Very High
Cv Unclassified Under Development 25 90.36 High High
Cancer 3 88.72 High High
Hyperalgesia 13 82.52 Quite High
Apoptosis 11 66.24 Quite High
Pain 31 62.88 Quite High
Epilepsy 29 57.96 Quite High
Depression 7 55.68 Quite High
Necrosis 8 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A structural study of tomosyn indicated that the C-terminal VAMP-like domain (VLD) of tomosyn acts as a SNARE domain that competes with VAMP-2, leading to inhibition of the formation of the SNARE complex (Pobbati et al., 2004).
Gene_expression (domain) of SNARE
1) Confidence 0.51 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.09 Pain Relevance 0
Paw withdrawal latency to thermal stimuli (three stimuli per time point) were measured and averaged at 30 minutes post injection. 25 mM SNAP solution in PBS was prepared right before injection by dissolving 2.5 M stock in DMSO.
Gene_expression (solution) of SNAP in Paw associated with withdrawal
2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0.29 Pain Relevance 0.36
In the present study, the expression of SNAP-25, a t-SNARE protein essential for vesicle release, was found to be dramatically regulated in hippocampus after chronic morphine treatment, which was visualized with two-dimensional gel electrophoresis.
Gene_expression (expression) of SNARE in hippocampus associated with hippocampus and morphine
3) Confidence 0.11 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.50
To investigate this, specimens from ventricles of rat hearts were randomized to receive the exogenous NO donor SNAP (100 ?
Gene_expression (receive) of SNAP in hearts
4) Confidence 0.08 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.56 Pain Relevance 0.09
The SNARE complex level is expressed as a 7S complex to monomer (syntaxin) ratio and normalized to that in control (CS) flies at room temperature.
Gene_expression (expressed) of SNARE
5) Confidence 0.06 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808484 Disease Relevance 0 Pain Relevance 0
Using an innovative transgenic mouse model expressing a dominant negative SNARE domain to selectively block astrocytic ATP release, Pascual et al. [89] elegantly showed that astrocytic purinergic signalling coordinates synaptic networks.
Neg (negative) Gene_expression (expressing) of SNARE associated with targeted disruption
6) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.21 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox