INT120334

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.71
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
neuronal 4
neurons 2
neural 2
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 207 100.00 Very High Very High Very High
Morphine 21 99.78 Very High Very High Very High
Neuronal excitability 6 98.72 Very High Very High Very High
opiate 6 96.20 Very High Very High Very High
Hippocampus 9 86.52 High High
Neurotransmitter 6 85.44 High High
Inflammation 9 69.48 Quite High
Central nervous system 30 66.00 Quite High
long-term potentiation 3 60.56 Quite High
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Virus Diseases 267 97.86 Very High Very High Very High
Cognitive Disorder 9 93.96 High High
Attention Deficit Hyperactivity Disorder 3 93.44 High High
Infection 87 87.32 High High
Congenital Anomalies 6 83.80 Quite High
Borna Disease 12 75.00 Quite High
INFLAMMATION 9 69.48 Quite High
Neurological Disease 12 57.64 Quite High
Disease 18 30.08 Quite Low
Respiratory Syncytial Virus 3 27.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, neurons infected with this mutant virus exhibited a normal pattern of phosphorylation of the PKC endogenous substrates MARCKS and SNAP-25.
Negative_regulation (pattern) of Phosphorylation (phosphorylation) of SNAP-25 in neurons associated with kinase c
1) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.83 Pain Relevance 0.50
Nevertheless, as BDV is likely to affect all PKC neuronal substrates in the infected neurons, the relative contribution of the decreased phosphorylation of each of these substrates, including SNAP-25, is difficult to appreciate.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of SNAP-25 in neuronal associated with virus diseases and kinase c
2) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.81 Pain Relevance 0.27
Thus, these results indicate that chronic morphine treatment inhibits phosphorylation of SNAP-25 at Ser187 and leads to a down-regulation of SNARE complex formation, which presents a potential molecular mechanism for the alteration of exocytotic process and neural plasticity during opiate abuse.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of SNAP-25 in neural associated with opiate and morphine
3) Confidence 0.34 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.85
Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation.
Negative_regulation (Inhibition) of Phosphorylation (phosphorylation) of SNAP-25 associated with morphine
4) Confidence 0.34 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.55
Indeed, PKC phosphorylation of SNAP-25, by promoting inhibition of VGCCs decreases calcium signaling and controls neuronal excitability.
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of SNAP-25 in neuronal associated with kinase c and neuronal excitability
5) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.07 Pain Relevance 0.32
Immunoblotting analysis with specific antibody to Ser187, a protein kinase C (PKC) phosphorylation site of SNAP-25, revealed that the specific phosphorylation was correspondingly decreased, which was correlated with morphine-induced inhibition of PKC activity.
Negative_regulation (site) of Phosphorylation (phosphorylation) of SNAP-25 associated with kinase c and morphine
6) Confidence 0.25 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.73

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox