INT120335

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 9.44
Pain Relevance 5.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
neuronal 2
neurons 2
nerve 1
cartilage 1
cleavage 1
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 10 99.28 Very High Very High Very High
Opioid 39 98.72 Very High Very High Very High
Neurotransmitter 16 98.56 Very High Very High Very High
Morphine 209 98.32 Very High Very High Very High
substance P 88 97.76 Very High Very High Very High
qutenza 6 97.56 Very High Very High Very High
alcohol 8 97.12 Very High Very High Very High
Hippocampus 6 96.28 Very High Very High Very High
Kinase C 79 95.28 Very High Very High Very High
Pain 47 91.64 High High
Disease Link Frequency Relevance Heat
Cancer 156 98.92 Very High Very High Very High
Disease 409 98.76 Very High Very High Very High
Schizophrenia 14 98.76 Very High Very High Very High
Manic Depressive Disorder 10 98.68 Very High Very High Very High
Nicotine Addiction 5 97.92 Very High Very High Very High
Targeted Disruption 4 96.36 Very High Very High Very High
Anaplastic Astrocytoma 1 96.04 Very High Very High Very High
Infection 31 95.44 Very High Very High Very High
Clostridium Infection 1 95.32 Very High Very High Very High
Chronic Disease 4 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of synaptic functions and more specifically, decreased expression of synaptic vesicle proteins such as SNAP-25 is one of the main effects of ALZ [13],[14].
Gene_expression (expression) of SNAP-25 in synaptic vesicle associated with disease
1) Confidence 0.65 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816673 Disease Relevance 2.47 Pain Relevance 0.05
In particular, the levels of protein SNAP-25 was shown to be reduced in both BIP and SCHZ [17].
Gene_expression (levels) of protein SNAP-25 associated with manic depressive disorder and schizophrenia
2) Confidence 0.57 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816673 Disease Relevance 2.32 Pain Relevance 0.04
Tandem RE1s were originally identified in the SNAP25 gene (26), which could recruit REST at low cellular concentrations such as that found in the U373 astrocytoma cell line.
Gene_expression (identified) of SNAP25 associated with anaplastic astrocytoma
3) Confidence 0.52 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.16 Pain Relevance 0
Our experiments demonstrate that NI-hADSCs express increased immunoreactivities for neuronal markers Tuj1, MAP2, NFL, NFM, NFH, NSE, NeuN, GAP43, and SNAP25, as well as the increased mRNA expression of Tuj1, MAP2, NFL, NFM, NSE, GAP43, and SNAP25 compared to primary hADSCs (Figure 3), indicating that hADSCs differentiate into neural cells via bFGF and forskolin-mediated differentiation.
Gene_expression (expression) of SNAP25 in neuronal
4) Confidence 0.48 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.04
Our experiments demonstrate that NI-hADSCs express increased immunoreactivities for neuronal markers Tuj1, MAP2, NFL, NFM, NFH, NSE, NeuN, GAP43, and SNAP25, as well as the increased mRNA expression of Tuj1, MAP2, NFL, NFM, NSE, GAP43, and SNAP25 compared to primary hADSCs (Figure 3), indicating that hADSCs differentiate into neural cells via bFGF and forskolin-mediated differentiation.
Gene_expression (express) of SNAP25 in neuronal
5) Confidence 0.48 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.04
In the present study, the expression of SNAP-25, a t-SNARE protein essential for vesicle release, was found to be dramatically regulated in hippocampus after chronic morphine treatment, which was visualized with two-dimensional gel electrophoresis.
Gene_expression (expression) of SNAP-25 in hippocampus associated with hippocampus and morphine
6) Confidence 0.45 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.50
Accordingly, SUP-A-004 was synthesized in its mirror-image configuration using l-phosphoramidites.
Gene_expression (synthesized) of SUP-A-004
7) Confidence 0.43 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.17
Likewise, we also demonstrated the restoration of phospho-MARCKS and phospho-SNAP25 levels in neurons infected with rBDV-LLSS, with levels being comparable to those observed in non-infected neurons following PKC stimulation (Figure 4C).
Gene_expression (levels) of SNAP25 in neurons associated with kinase c
8) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.59 Pain Relevance 0.14
Expression of a subset of the validated bovine markers genes (KRT8, 18, 19 SNAP25, CDH2, TNMD, BASP1, FOXF1, IBSP and FBLN 1) was analysed in human cells.
Spec (analysed) Gene_expression (Expression) of SNAP25
9) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Further analysis of SNARE complex formed by transfection of the wild-type or Ser187 mutants of SNAP-25 showed that only wild-type-formed complex was inhibited by morphine treatment.
Gene_expression (transfection) of SNAP-25 associated with morphine
10) Confidence 0.39 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.90
An efficacy trial of brief lifestyle intervention delivered by generalist community nurses (CN SNAP trial)

Background

Gene_expression (trial) of SNAP
11) Confidence 0.38 Published 2010 Journal BMC Nurs Section Title Doc Link PMC2841173 Disease Relevance 0.19 Pain Relevance 0.05
Neuroendocrine marker SNAP25 (b) and pituitary hormone FSH?
Gene_expression (marker) of SNAP25 in pituitary
12) Confidence 0.33 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 1.43 Pain Relevance 0
Analysis of NP-specific marker genes in degenerate samples (Figure 6a) showed a significant decrease in expression for SNAP25, KRT8, KRT18 and CDH2 in degenerate NP cells when compared with normal NP cells (P = 0.0002, P = 0.0003, P < 0.0001 and P = 0.0001, respectively).
Gene_expression (expression) of SNAP25
13) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
N-cadherin (CDH2) was also highly differentially expressed and was selected along with synaptosomal-associated protein, 25 kDa (SNAP25) and sclerostin domain containing 1 (SOSTDC1) as NP-specific markers for further analysis.
Gene_expression (expressed) of synaptosomal-associated protein
14) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.17 Pain Relevance 0
Analysis of the NP-specific marker genes (SNAP25, KRT8, KRT18, KRT19, CDH2 and SOSTDC1; Figure 3a) demonstrated significantly higher expression in NP cells when compared with either AF (all genes P < 0.0001) or AC cells (all genes P < 0.0001), which confirmed the microarray findings.
Gene_expression (expression) of SNAP25
15) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Eleven genes (SNAP25, KRT8, KRT18, KRT19, CDH2, IBSP, VCAN, TNMD, BASP1, FOXF1 & FBLN1) were also differentially expressed in normal human NP cells, although to a lesser degree.
Gene_expression (expressed) of SNAP25
16) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
The half-maximum inhibition (IC50) was achieved at an l-SUP-A-004 concentration of ?
Gene_expression (concentration) of l-SUP-A-004
17) Confidence 0.32 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.32
Hence, converging evidence continues to emerge for the sequential formation of complexes between the three SNAREs (SNAP-25, syntaxin and VAMP) and their regulatory proteins (complexins, Munc18), as well as for the Ca2+ triggering of membrane fusion/exocytosis via its sensor, synaptotagmin.
Gene_expression (formation) of SNAP-25
18) Confidence 0.28 Published 2009 Journal Curr Opin Pharmacol Section Abstract Doc Link 19394272 Disease Relevance 0.15 Pain Relevance 0.09
Hence, converging evidence continues to emerge for the sequential formation of complexes between the three SNAREs (SNAP-25, syntaxin and VAMP) and their regulatory proteins (complexins, Munc18), as well as for the Ca2+ triggering of membrane fusion/exocytosis via its sensor, synaptotagmin.
Gene_expression (syntaxin) of SNAP-25
19) Confidence 0.28 Published 2009 Journal Curr Opin Pharmacol Section Abstract Doc Link 19394272 Disease Relevance 0.15 Pain Relevance 0.09
Only the addition of SNAP 100 ?
Gene_expression (addition) of SNAP
20) Confidence 0.26 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004619 Disease Relevance 0 Pain Relevance 0.63

General Comments

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