INT120336

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
neuronal 6
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 97.76 Very High Very High Very High
Kinase C 4 93.44 High High
adenocard 3 88.72 High High
opiate 2 70.96 Quite High
Hippocampus 4 64.08 Quite High
Neurotransmitter 1 57.64 Quite High
tetrodotoxin 36 5.00 Very Low Very Low Very Low
sodium channel 12 5.00 Very Low Very Low Very Low
potassium channel 12 5.00 Very Low Very Low Very Low
Calcium channel 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 57 50.00 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our experiments demonstrate that NI-hADSCs express increased immunoreactivities for neuronal markers Tuj1, MAP2, NFL, NFM, NFH, NSE, NeuN, GAP43, and SNAP25, as well as the increased mRNA expression of Tuj1, MAP2, NFL, NFM, NSE, GAP43, and SNAP25 compared to primary hADSCs (Figure 3), indicating that hADSCs differentiate into neural cells via bFGF and forskolin-mediated differentiation.
Positive_regulation (increased) of Gene_expression (expression) of SNAP25 in neuronal
1) Confidence 0.37 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.04
Our experiments demonstrate that NI-hADSCs express increased immunoreactivities for neuronal markers Tuj1, MAP2, NFL, NFM, NFH, NSE, NeuN, GAP43, and SNAP25, as well as the increased mRNA expression of Tuj1, MAP2, NFL, NFM, NSE, GAP43, and SNAP25 compared to primary hADSCs (Figure 3), indicating that hADSCs differentiate into neural cells via bFGF and forskolin-mediated differentiation.
Positive_regulation (increased) of Gene_expression (expression) of SNAP25 in neuronal
2) Confidence 0.37 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.04
Our experiments demonstrate that NI-hADSCs express increased immunoreactivities for neuronal markers Tuj1, MAP2, NFL, NFM, NFH, NSE, NeuN, GAP43, and SNAP25, as well as the increased mRNA expression of Tuj1, MAP2, NFL, NFM, NSE, GAP43, and SNAP25 compared to primary hADSCs (Figure 3), indicating that hADSCs differentiate into neural cells via bFGF and forskolin-mediated differentiation.
Positive_regulation (immunoreactivities) of Gene_expression (expression) of SNAP25 in neuronal
3) Confidence 0.37 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.04
Further analysis of SNARE complex formed by transfection of the wild-type or Ser187 mutants of SNAP-25 showed that only wild-type-formed complex was inhibited by morphine treatment.
Positive_regulation (transfection) of Gene_expression (transfection) of SNAP-25 associated with morphine
4) Confidence 0.29 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.90

General Comments

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