INT120337

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.11
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
neural 2
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 69 100.00 Very High Very High Very High
Morphine 7 99.60 Very High Very High Very High
opiate 2 93.32 High High
Neurotransmitter 2 89.96 High High
Neuronal excitability 2 87.68 High High
Hippocampus 3 55.76 Quite High
Central nervous system 10 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 29 56.72 Quite High
Virus Diseases 89 53.68 Quite High
Borna Disease 4 50.00 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Viral Infection 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, these results indicate that chronic morphine treatment inhibits phosphorylation of SNAP-25 at Ser187 and leads to a down-regulation of SNARE complex formation, which presents a potential molecular mechanism for the alteration of exocytotic process and neural plasticity during opiate abuse.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of SNAP-25 in neural associated with opiate and morphine
1) Confidence 0.29 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.85
It has recently been shown that activity-dependent phosphorylation of SNAP-25 is mediated by PKC and is required for negative regulation of VGCCs [35].
Positive_regulation (required) of Phosphorylation (phosphorylation) of SNAP-25 associated with kinase c
2) Confidence 0.29 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.11 Pain Relevance 0.35

General Comments

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