INT120339

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 2.97
Pain Relevance 5.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SNAP25) small molecule metabolic process (SNAP25) plasma membrane (SNAP25)
cytoplasm (SNAP25)
Anatomy Link Frequency
neurons 3
neuronal 2
neural 1
SNAP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 471 100.00 Very High Very High Very High
Morphine 28 99.60 Very High Very High Very High
Neuronal excitability 14 96.96 Very High Very High Very High
opiate 8 96.20 Very High Very High Very High
Neurotransmitter 11 89.96 High High
Hippocampus 18 86.52 High High
long-term potentiation 7 83.12 Quite High
Inflammation 21 69.04 Quite High
Central nervous system 70 65.56 Quite High
antagonist 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 203 98.70 Very High Very High Very High
Virus Diseases 623 98.02 Very High Very High Very High
Cognitive Disorder 21 93.56 High High
Attention Deficit Hyperactivity Disorder 7 93.04 High High
Congenital Anomalies 14 90.72 High High
Borna Disease 28 75.00 Quite High
INFLAMMATION 21 69.04 Quite High
Neurological Disease 28 57.20 Quite High
Respiratory Syncytial Virus 7 50.04 Quite High
Disease 42 30.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, neurons infected with this mutant virus exhibited a normal pattern of phosphorylation of the PKC endogenous substrates MARCKS and SNAP-25.
Phosphorylation (phosphorylation) of SNAP-25 in neurons associated with kinase c
1) Confidence 0.51 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673689 Disease Relevance 0.83 Pain Relevance 0.50
Indeed, PKC phosphorylation of SNAP-25, by promoting inhibition of VGCCs decreases calcium signaling and controls neuronal excitability.
Phosphorylation (phosphorylation) of SNAP-25 in neuronal associated with kinase c and neuronal excitability
2) Confidence 0.51 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.06 Pain Relevance 0.31
Nevertheless, as BDV is likely to affect all PKC neuronal substrates in the infected neurons, the relative contribution of the decreased phosphorylation of each of these substrates, including SNAP-25, is difficult to appreciate.
Phosphorylation (phosphorylation) of SNAP-25 in neuronal associated with virus diseases and kinase c
3) Confidence 0.51 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.81 Pain Relevance 0.24
It has recently been shown that activity-dependent phosphorylation of SNAP-25 is mediated by PKC and is required for negative regulation of VGCCs [35].
Phosphorylation (phosphorylation) of SNAP-25 associated with kinase c
4) Confidence 0.51 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.11 Pain Relevance 0.34
This led us to investigate whether the differences observed between neurons infected with rBDV-wt and rBDV-AASS in the phosphorylation of SNAP25 would have an impact on their calcium responsiveness upon depolarization.
Phosphorylation (phosphorylation) of SNAP25 in neurons
5) Confidence 0.51 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.14 Pain Relevance 0.26
Thus, these results indicate that chronic morphine treatment inhibits phosphorylation of SNAP-25 at Ser187 and leads to a down-regulation of SNARE complex formation, which presents a potential molecular mechanism for the alteration of exocytotic process and neural plasticity during opiate abuse.
Phosphorylation (phosphorylation) of SNAP-25 in neural associated with opiate and morphine
6) Confidence 0.48 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.84
Immunoblotting analysis with specific antibody to Ser187, a protein kinase C (PKC) phosphorylation site of SNAP-25, revealed that the specific phosphorylation was correspondingly decreased, which was correlated with morphine-induced inhibition of PKC activity.
Phosphorylation (phosphorylation) of SNAP-25 associated with kinase c and morphine
7) Confidence 0.48 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.73
Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation.
Phosphorylation (phosphorylation) of SNAP-25 associated with morphine
8) Confidence 0.48 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.55
To determine the impact of the destruction of the PKC phosphorylation sites on BDV P, we directly stimulated the PKC pathway of neurons using the phorbol ester PMA and analyzed the phosphorylation status of two major PKC targets in neurons, myristoylated alanine-rich C kinase substrate (MARCKS) and synaptosomal-associated protein of 25 kDa (SNAP25) [32],[33].
Phosphorylation (phosphorylation) of SNAP25 in neurons associated with virus diseases and kinase c
9) Confidence 0.44 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.34 Pain Relevance 0.34
The calcium hyper-excitability in response to depolarization that we observed after infection with rBDV-wt is consistent with a recent study showing that non-phosphorylable (S187A) SNAP-25 mutants also display increased calcium responsiveness [35].
Phosphorylation (phosphorylable) of SNAP-25 associated with infection
10) Confidence 0.39 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673689 Disease Relevance 0.69 Pain Relevance 0.24
This suggests a causal relationship between the inhibition of PKC-dependent SNAP-25 phosphorylation and the down-regulation of SNARE complex formation after chronic morphine treatment.
Phosphorylation (phosphorylation) of SNAP-25 associated with kinase c and morphine
11) Confidence 0.37 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15277518 Disease Relevance 0 Pain Relevance 0.94

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