INT12034

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.25
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
plasma membrane (Umod)
Anatomy Link Frequency
urine 2
brain 1
Umod (Mus musculus)
Pain Link Frequency Relevance Heat
interstitial cystitis 12 99.84 Very High Very High Very High
Inflammation 2 87.24 High High
Dismenorea 1 83.28 Quite High
Dysuria 1 60.64 Quite High
anesthesia 2 58.00 Quite High
Pain 1 56.84 Quite High
antagonist 1 49.20 Quite Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 12 99.84 Very High Very High Very High
Anaemia 1 94.80 High High
Balkan Nephropathy 4 94.00 High High
Glioma 2 89.20 High High
Bacteriuria 1 87.96 High High
INFLAMMATION 2 87.24 High High
Uremia 3 82.48 Quite High
Proteinuria 2 80.44 Quite High
Cancer 2 78.64 Quite High
Syndrome 1 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis.
Positive_regulation (Increased) of Tamm-Horsfall glycoprotein associated with interstitial cystitis
1) Confidence 0.69 Published 1996 Journal J. Urol. Section Title Doc Link 8709369 Disease Relevance 0.10 Pain Relevance 0.19
Tamm-Horsfall protein may be increased in the urine.
Spec (may) Positive_regulation (increased) of Tamm-Horsfall protein in urine
2) Confidence 0.59 Published 1992 Journal Food Chem. Toxicol. Section Abstract Doc Link 1618441 Disease Relevance 1.55 Pain Relevance 0.12
The humoral response to Tamm-Horsfall protein in these patients suggests a role for Tamm-Horsfall protein in interstitial cystitis.
Positive_regulation (response) of Tamm-Horsfall protein associated with interstitial cystitis
3) Confidence 0.45 Published 1991 Journal J. Urol. Section Abstract Doc Link 1984095 Disease Relevance 0.56 Pain Relevance 0.44
The humoral response to Tamm-Horsfall protein in these patients suggests a role for Tamm-Horsfall protein in interstitial cystitis.
Positive_regulation (role) of Tamm-Horsfall protein associated with interstitial cystitis
4) Confidence 0.39 Published 1991 Journal J. Urol. Section Abstract Doc Link 1984095 Disease Relevance 0.55 Pain Relevance 0.44
Characterization of the Fabry-Rag mouse showed that urine uromodulin levels were significantly elevated.
Positive_regulation (elevated) of uromodulin in urine
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
We hypothesize that the high levels of E2 in pregnancy attenuate the increase in the conversion of P to THP in the brain and that the ratio of E2/P modulates the sedative effect of THP.
Positive_regulation (increase) of THP in brain
6) Confidence 0.35 Published 2004 Journal Brain Res. Section Abstract Doc Link 15312799 Disease Relevance 0.31 Pain Relevance 0.08
Although the levels of urinary beta 2-microglobulin and albumin after ESWL were significantly higher (p < 0.05) than the pre-ESWL levels in group 3, the changes in urinary albumin and Tamm-Horsfall protein were milder in group 3 than in group 1.
Positive_regulation (changes) of Tamm-Horsfall protein
7) Confidence 0.12 Published 1995 Journal J. Urol. Section Abstract Doc Link 7861490 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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