INT12035

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 12.66
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
liver 4
blood 3
plasma 3
platelet 3
chest 1
F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 3 99.32 Very High Very High Very High
peripheral neuropathy 1 98.32 Very High Very High Very High
Pain 12 97.68 Very High Very High Very High
cytokine 28 96.44 Very High Very High Very High
Chronic pancreatitis 2 93.16 High High
fibrosis 9 92.84 High High
imagery 23 88.48 High High
anesthesia 6 86.88 High High
Inflammation 59 81.44 Quite High
pruritus 22 63.64 Quite High
Disease Link Frequency Relevance Heat
Acid Base Imbalance 2 100.00 Very High Very High Very High
Hemorrhage 88 99.96 Very High Very High Very High
Myocardial Infarction 58 99.54 Very High Very High Very High
Coagulation Disorder 13 99.32 Very High Very High Very High
Cystitis 1 99.24 Very High Very High Very High
Disease Progression 5 98.84 Very High Very High Very High
Overdose 2 98.84 Very High Very High Very High
Sepsis 108 98.78 Very High Very High Very High
Hirsutism 1 98.72 Very High Very High Very High
Peripheral Neuropathy 1 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Physicians should be instructed regarding the possible manifestations of TCDD exposure to look for chloracne, soft tissue masses, muscle pain, fatigue, peripheral neuropathy, tender hepatic enlargement, enlargement, elevated liver enzymes, elevated lipids, prolonged prothrombin time, hemorrhagic cystitis and hirsutism.
Regulation (prolonged) of prothrombin in liver associated with hirsutism, pain, cystitis, fatigue, peripheral neuropathy, myalgia and chloracne
1) Confidence 0.45 Published 1985 Journal Vet Hum Toxicol Section Abstract Doc Link 4060565 Disease Relevance 0.72 Pain Relevance 0.15
OBJECTIVE: To explore the effect of intravenous N-acetylcysteine (NAC) on the prothrombin time (PT) in patients with paracetamol overdose and persistent normal liver profile.
Regulation (effect) of prothrombin in liver associated with paracetamol and overdose
2) Confidence 0.44 Published 2005 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 15647642 Disease Relevance 0.17 Pain Relevance 0.17
Severe sepsis was defined as sepsis with evidence of organ dysfunction and hypoperfusion, acute alteration of mental status, elevated plasma lactate, unexplained metabolic acidosis (arterial pH <7.3), hypoxaemia, prolonged prothrombin time or a decrease in platelet count >50% or ?
Regulation (prolonged) of prothrombin in platelet associated with acid base imbalance and sepsis
3) Confidence 0.44 Published 2010 Journal Crit Care Section Body Doc Link PMC2887140 Disease Relevance 1.49 Pain Relevance 0
Severe sepsis was defined as sepsis with evidence of organ dysfunction and hypoperfusion, acute alteration of mental status, elevated plasma lactate, unexplained metabolic acidosis (arterial pH <7.3), hypoxaemia, prolonged prothrombin time or a decrease in platelet count >50% or ?
Regulation (alteration) of prothrombin in platelet associated with acid base imbalance and sepsis
4) Confidence 0.44 Published 2010 Journal Crit Care Section Body Doc Link PMC2887140 Disease Relevance 1.55 Pain Relevance 0
Prothrombin time (INR, international normalized ratio) is prolonged by dabigatran but is less sensitive than thrombin time and ecarin clotting time.39
Regulation (sensitive) of thrombin associated with coagulation disorder
5) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 0.35 Pain Relevance 0.03
Prothrombin time (INR, international normalized ratio) is prolonged by dabigatran but is less sensitive than thrombin time and ecarin clotting time.39
Regulation (sensitive) of Prothrombin associated with coagulation disorder
6) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 0.36 Pain Relevance 0.03
However, there is no evidence that in myocardial infarction patients such therapy alters thrombin formation or platelet activation.
Regulation (alters) of thrombin in platelet associated with myocardial infarction
7) Confidence 0.36 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.89 Pain Relevance 0.03
The effects of thrombin (0.5 to 5.0 U/mL) and a specific protease-activated receptor 1-activating peptide (1 nmol/L to 10 micromol/L) on integrals of contractile activity were measured and compared with control values.
Regulation (effects) of thrombin
8) Confidence 0.36 Published 2004 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 15118649 Disease Relevance 0 Pain Relevance 0
There was no significant drug-exposure-related change in the chest radiogram, electrocardiogram, electroencephalogram, urinalysis results, complete blood count, prothrombin time, serum electrolytes, transaminases, or hepatic and renal functions during four weeks following exposure compared wth preexposure values.
Regulation (change) of prothrombin in chest
9) Confidence 0.27 Published 1981 Journal Anesthesiology Section Abstract Doc Link 6781380 Disease Relevance 0 Pain Relevance 0.15
The present study was designed to examine the effects of synthetic serine protease inhibitors (FOY-007 and FOY-305) on proliferation and collagen synthesis of hPFCs under cytokine stimulation.
Spec (examine) Regulation (effects) of serine protease associated with cytokine
10) Confidence 0.18 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.18 Pain Relevance 0.18
Effects of synthetic serine protease inhibitors on proliferation and collagen synthesis of human pancreatic periacinar fibroblast-like cells.
Regulation (Effects) of serine protease in fibroblast
11) Confidence 0.15 Published 2001 Journal Pancreas Section Title Doc Link 11291936 Disease Relevance 0.18 Pain Relevance 0.17
Effect of thrombin treatment on hUtSMC collagen contractility
Regulation (Effect) of thrombin
12) Confidence 0.12 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
The study showed a dose-dependent inhibition of FXa and an additional prolongation of prothrombin time (PT), which correlated with the plasma concentration of rivaroxaban.
Regulation (prolongation) of prothrombin in plasma
13) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.39 Pain Relevance 0.03
The study showed a dose-dependent inhibition of FXa and an additional prolongation of prothrombin time (PT), which correlated with the plasma concentration of rivaroxaban.
Regulation (prolongation) of PT in plasma
14) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.39 Pain Relevance 0.03
The vehicle controls for thrombin, hirudin, TNF?
Regulation (controls) of thrombin
15) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Even though liver function tests such as albumin and prothrombin time became extremely abnormal during the course of the experiment, the dogs did not become encephalopathic.
Regulation (abnormal) of prothrombin in liver
16) Confidence 0.07 Published 1992 Journal Hepatology Section Abstract Doc Link 1618484 Disease Relevance 0.40 Pain Relevance 0.09
Blood examination for bleeding, coagulation, prothrombin and partial thromboplastin times yielded normal results.
Regulation (coagulation) of prothrombin in Blood associated with hemorrhage
17) Confidence 0.06 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913532 Disease Relevance 0.66 Pain Relevance 0.08
No pathological values for prothrombin time ratio, activated partial thromboplastin time, plasma antithrombin III, protein C and S activity were found.
Neg (No) Regulation (values) of prothrombin in plasma
18) Confidence 0.06 Published 2005 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1198216 Disease Relevance 1.44 Pain Relevance 0.14
The therapeutic effects on systemic blood pressure and organ failure, however, could not be explained on the basis of its direct effect on thrombin.
Regulation (effect) of thrombin in blood
19) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.38 Pain Relevance 0.12
2GPI related synthetic peptides and structures within bacteria, viruses (e.g., cytomegalovirus) and the tetanus toxoid could explain the appearance of APS in such conditions (see below).13 Additional pathways where aPLs interfere with the regulation of protein C, annexin V, prothrombin, and tissue factor have also been suggested.12,13

(iv) The fourth approach to thrombosis in APS is related to heparin-induced thrombocytopenia (a thrombosis in multiple arterial and venous beds is observed in both pathologies).

Regulation (regulation) of prothrombin associated with anti-phospholipid antibody syndrome, heparin-induced thrombocytopenia, anaerobic bacterial infections, cytomegalovirus infection and thrombosis related under development
20) Confidence 0.05 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.25 Pain Relevance 0

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