INT120358

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.26
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1B) endosome (CDKN1B) nucleoplasm (CDKN1B)
nucleus (CDKN1B) cell cycle (CDKN1B) kinase activity (CDKN1B)
Anatomy Link Frequency
HT-29 2
CDKN1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 93.44 High High
fortral 2 88.68 High High
Potency 1 85.56 High High
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 2 100.00 Very High Very High Very High
Small Cell Lung Cancer 3 97.88 Very High Very High Very High
Alzheimer's Dementia 5 97.08 Very High Very High Very High
Cancer 28 75.00 Quite High
Disease 2 75.00 Quite High
Apoptosis 24 68.60 Quite High
INFLAMMATION 3 56.56 Quite High
Colon Cancer 25 51.04 Quite High
Death 5 5.00 Very Low Very Low Very Low
Malaria 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cyclopentenone induced a partial inhibition of retinoblastoma protein phosphorylation and increased levels of the CDK inhibitor p27kip1.
Spec (partial) Positive_regulation (induced) of Positive_regulation (increased) of p27kip1 associated with retinoblastoma
1) Confidence 0.49 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16061222 Disease Relevance 0.77 Pain Relevance 0.34
Interestingly, K+ channel blockers and sigma ligands caused an accumulation of the cyclin-dependent kinase inhibitor p27kip1 and a decrease in cyclin A expression in Jurkat and SCLC cells, whereas no effect could be detected on p21cip1.
Positive_regulation (caused) of Positive_regulation (accumulation) of p27kip1 associated with small cell lung cancer
2) Confidence 0.45 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15277583 Disease Relevance 0.45 Pain Relevance 0.21
The G0/G1 arrest of HT-29 cells induced by 5-FU and potentiated by CQ was dependent on the increase of p21Cip1and p27Kip1, and decrease of CDK2
Positive_regulation (dependent) of Positive_regulation (increase) of p27Kip1 in HT-29
3) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox