INT120372

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Context Info
Confidence 0.21
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 21.10
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ambp) extracellular region (Ambp) plasma membrane (Ambp)
protein maturation (Ambp)
Anatomy Link Frequency
bladder 6
kidney 3
Ambp (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 21 99.40 Very High Very High Very High
Inflammation 227 96.92 Very High Very High Very High
Versed 17 96.48 Very High Very High Very High
Inflammatory mediators 85 95.92 Very High Very High Very High
cINOD 2 94.32 High High
corticosteroid 2 92.64 High High
cytokine 71 91.08 High High
chemokine 102 87.80 High High
Inflammatory response 105 86.92 High High
imagery 51 69.48 Quite High
Disease Link Frequency Relevance Heat
Urinary Tract Infection 950 100.00 Very High Very High Very High
Targeted Disruption 697 99.44 Very High Very High Very High
Infection 653 98.72 Very High Very High Very High
Pneumococcal Infection 51 98.48 Very High Very High Very High
Sprains And Strains 282 98.24 Very High Very High Very High
INFLAMMATION 419 96.92 Very High Very High Very High
Sepsis 74 96.12 Very High Very High Very High
Cystitis 60 93.04 High High
Shock 23 92.04 High High
Pyelonephritis 49 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study aimed to evaluate the potential efficacy of immunomodulating therapy using Ulinastatin (UTI) plus Thymosin alpha1 (Talpha1) for improving organ function and reducing mortality in patients with severe sepsis.
Positive_regulation (using) of UTI associated with sepsis and urinary tract infection
1) Confidence 0.21 Published 2009 Journal Chin. Med. J. Section Abstract Doc Link 19493408 Disease Relevance 0.46 Pain Relevance 0.14
This study aimed to evaluate the potential efficacy of immunomodulating therapy using Ulinastatin (UTI) plus Thymosin alpha1 (Talpha1) for improving organ function and reducing mortality in patients with severe sepsis.
Positive_regulation (using) of Ulinastatin associated with sepsis and urinary tract infection
2) Confidence 0.19 Published 2009 Journal Chin. Med. J. Section Abstract Doc Link 19493408 Disease Relevance 0.46 Pain Relevance 0.14
The other 8 patients were administered totally 300,000 units of Ulinastatin after induction until the second measurement of TEG, thereafter FFP was transfused (group II).
Positive_regulation (induction) of Ulinastatin
3) Confidence 0.17 Published 1991 Journal J Anesth Section Abstract Doc Link 15278667 Disease Relevance 0.09 Pain Relevance 0.09
Mice were sacrificed 24 or 48 hours after the induction of UTI.
Positive_regulation (induction) of UTI associated with urinary tract infection
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.43 Pain Relevance 0.13
Coli-induced UTI.
Positive_regulation (induced) of UTI associated with urinary tract infection
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.09 Pain Relevance 0.13
Coli-induced UTI.
Positive_regulation (induced) of UTI associated with urinary tract infection
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.57 Pain Relevance 0.16
Urinary tract infection (UTI) was induced as described earlier [19], [20], [21].
Positive_regulation (induced) of UTI associated with urinary tract infection
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.15 Pain Relevance 0.11
This study is the first to describe the contribution of S100A8/A9 during (E.coli-induced) UTI using S100A9 KO mice.
Positive_regulation (induced) of UTI associated with targeted disruption and urinary tract infection
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.10 Pain Relevance 0.12
In addition, U. parvum-induced complicated UTI in rats, leads to higher expression of S100A8/A9 complex in bladder tissue compared to bladders from animals with asymptomatic UTI [17].
Positive_regulation (induced) of UTI in bladders associated with urinary tract infection
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.24 Pain Relevance 0.15
Although the manner by which pathogen-host interaction occurs during E.coli-induced UTI is slowly beginning to unravel [7], the contribution of DAMPs released upon inflammation is less clear.
Positive_regulation (induced) of UTI associated with inflammation and urinary tract infection
10) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.22 Pain Relevance 0.20
These data are in line with our results demonstrating that during UTI, levels of S100A8/A9 increased in both bladder and kidney homogenates.
Positive_regulation (increased) of UTI in bladder associated with urinary tract infection
11) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.05 Pain Relevance 0.11
First, we determined S100A8/A9 protein complex expression in bladder and kidney tissue from WT mice upon UTI induced by 9×108 CFU/mouse.
Positive_regulation (induced) of UTI in kidney associated with urinary tract infection
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.26 Pain Relevance 0.07
Reyes et al. showed that Ureaplasma parvum-induced UTI lead to increased S100A8/A9 expression in bladder tissue however, its contribution was not further investigated [17].
Positive_regulation (induced) of UTI in bladder associated with urinary tract infection
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.28 Pain Relevance 0.12
UTI was induced under general anesthesia with 0.07 mL/10 g mouse of FFM mixture, containing 1.25 mg/mL midazolam (Roche, Mijdrecht, The Netherlands), 0.08 mg/mL fentanyl citrate and 2.5 mg/mL fluanisone (Janssen Pharmaceutica, Beerse, Belgium).
Positive_regulation (induced) of UTI associated with anesthesia, versed and urinary tract infection
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.65 Pain Relevance 0.15
UTI caused by uropathogenic E.coli is a substantial economical and social burden.
Positive_regulation (caused) of UTI associated with urinary tract infection
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 2.10 Pain Relevance 0.39
As shown in figure 1A–B, S100A8/A9 level was higher in bladder and kidney homogenates from WT mice 24 and 48 hours after induction of UTI compared to sham mice.
Positive_regulation (induction) of UTI in kidney associated with urinary tract infection
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.33 Pain Relevance 0.06
Therefore, we investigated the expression, localization and contribution of S100A8/A9 during E. coli-induced UTI.


Positive_regulation (induced) of UTI associated with urinary tract infection
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.40 Pain Relevance 0.08
Clinical UPEC isolates upregulate fimA during murine UTI
Positive_regulation (upregulate) of UTI associated with urinary tract infection
18) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 1.10 Pain Relevance 0
During murine experimental UTI, fimA was the fourth most highly-expressed gene and the other fim operon genes were also upregulated in vivo as compared to in vitro culture [4].
Positive_regulation (upregulated) of UTI associated with urinary tract infection
19) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.95 Pain Relevance 0.09
These data are in line with our results demonstrating that during UTI, levels of S100A8/A9 increased in both bladder and kidney homogenates.
Positive_regulation (increased) of UTI in kidney associated with urinary tract infection
20) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.05 Pain Relevance 0.11

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