INT120389

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PKLR) small molecule metabolic process (PKLR) carbohydrate metabolic process (PKLR)
PKLR (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 12 87.08 High High
b2 receptor 3 85.24 High High
Pain 1 60.00 Quite High
Crohn's disease 1 59.52 Quite High
Inflammation 1 57.12 Quite High
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 20 99.04 Very High Very High Very High
Cold Sores 6 97.52 Very High Very High Very High
Viral Infection 2 89.00 High High
Stress 3 87.92 High High
Hepatitis B Virus Infection 5 75.60 Quite High
Herpes Simplex Virus 1 75.04 Quite High
Breast Cancer 1 71.92 Quite High
Malignant Neoplastic Disease 1 67.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 61.88 Quite High
Pressure And Volume Under Development 1 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
phosphorylation through the double-stranded RNA-activated protein kinase (PKR).
Phosphorylation (phosphorylation) of PKR
1) Confidence 0.11 Published 2006 Journal Genome Biol Section Body Doc Link PMC1431708 Disease Relevance 1.43 Pain Relevance 0.03
Intracellular effects of B2 stimulation were the following: (a) the increase of free intracellular Ca(2+) concentration by a mechanism dependent upon the phospholipase C (PLC) activity; (b) the cytosol-to-membrane translocation of conventional (PKC)-alpha and -beta isozymes, novel PKC-delta, -epsilon, and -eta isozymes; (c) the phosphorylation of the extracellular-regulated kinase 1 and 2 (ERK1/2); and (d) the stimulation of the expression of c-Fos protein.
Phosphorylation (phosphorylation) of isozymes
2) Confidence 0.01 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0.38 Pain Relevance 0.48

General Comments

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