INT12039

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Context Info
Confidence 0.68
First Reported 1980
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 9.88
Pain Relevance 5.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TFPI) extracellular region (TFPI) plasma membrane (TFPI)
Anatomy Link Frequency
EPI 12
plasma 1
amygdala 1
mast cells 1
TFPI (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 18 100.00 Very High Very High Very High
amygdala 8 100.00 Very High Very High Very High
Enkephalin 8 99.56 Very High Very High Very High
aspirin 86 99.28 Very High Very High Very High
Dopamine 3 99.04 Very High Very High Very High
fibrosis 138 98.72 Very High Very High Very High
Neuropeptide 2 98.64 Very High Very High Very High
dexamethasone 4 97.04 Very High Very High Very High
metalloproteinase 3 96.96 Very High Very High Very High
Catecholamine 65 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 35 100.00 Very High Very High Very High
Immunization 17 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 100.00 Very High Very High Very High
Cancer 12 99.24 Very High Very High Very High
Pulmonary Disease 128 99.08 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 138 98.72 Very High Very High Very High
Cardiovascular Disease 60 98.28 Very High Very High Very High
Cv Unclassified Under Development 10 98.24 Very High Very High Very High
Systemic Sclerosis 107 98.12 Very High Very High Very High
Pressure And Volume Under Development 2 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The kinetics of FVIIa and F1+2 inhibition did not follow those of anti-Xa activity and TFPI release.
Localization (release) of TFPI
1) Confidence 0.68 Published 2003 Journal Br. J. Haematol. Section Abstract Doc Link 12588347 Disease Relevance 0.07 Pain Relevance 0.07
Calcium ionophore A23187 and anti-IgE caused histamine release from all bladder mast cells in a dose-related manner.
Localization (release) of anti-IgE in mast cells
2) Confidence 0.65 Published 1994 Journal Agents Actions Section Abstract Doc Link 7526643 Disease Relevance 0.35 Pain Relevance 0.33
The NE and EPI responses were attenuated after acute, bilateral adrenalectomies, confirming augmented adrenomedullary secretion, whereas the pressor responses were intact.
Localization (secretion) of EPI in EPI
3) Confidence 0.61 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1869769 Disease Relevance 0.50 Pain Relevance 0.84
NE and EPI were usually secreted simultaneously, but release of either NE or EPI alone occurred on some occasions.
Localization (release) of EPI in EPI
4) Confidence 0.61 Published 1988 Journal Surgery Section Abstract Doc Link 3194833 Disease Relevance 0.69 Pain Relevance 0.30
NE and EPI were usually secreted simultaneously, but release of either NE or EPI alone occurred on some occasions.
Localization (secreted) of EPI in EPI
5) Confidence 0.61 Published 1988 Journal Surgery Section Abstract Doc Link 3194833 Disease Relevance 0.70 Pain Relevance 0.30
However, no studies to date have directly measured changes in the release of NE in the amygdala after EPI injection.
Localization (release) of EPI in amygdala associated with amygdala
6) Confidence 0.49 Published 1998 Journal Behav. Neurosci. Section Abstract Doc Link 9926823 Disease Relevance 0 Pain Relevance 0.40
positive areas (Epi+Int and Epi) between the control, COPD and IPF groups differed significantly (Kruskal Wallis test; p = 0.007) while the Hb?
Localization (areas) of Epi associated with fibrosis and pulmonary disease
7) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.80 Pain Relevance 0.23
positive areas (Epi+Int and Epi) between the control, COPD and IPF groups differed significantly (Kruskal Wallis test; p = 0.007) while the Hb?
Localization (areas) of Epi associated with fibrosis and pulmonary disease
8) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.80 Pain Relevance 0.23
In conclusion, the implantable adapted Codman 3000 constant-flow infusion pump customized to anti-HIV therapy allows sustained release of anti-HIV medication and may represent an opportunity to reduce the pill burden and complexity of dosing schemes associated with common anti-HIV therapy.
Localization (release) of anti-HIV associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.41 Published 2008 Journal Int J Pharm Section Abstract Doc Link 18337029 Disease Relevance 0.72 Pain Relevance 0.11
To determine the relationship between insulin secretion during anesthesia and surgical stress and plasma levels of norepinephrine (NE) and epinephrine (Epi), studies were performed in 16 patients before and during elective minor surgical procedures.
Localization (secretion) of Epi in plasma associated with stress and anesthesia
10) Confidence 0.39 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6999007 Disease Relevance 0.65 Pain Relevance 0.47
subunit expressed and/or released upon EPI exposure.
Localization (released) of EPI in EPI
11) Confidence 0.31 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
Second, addition of propranolol attenuated EPI-mediated translocation of both GRK isoforms.
Localization (translocation) of EPI in EPI
12) Confidence 0.28 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
-ARs are present on the same cells lower, more physiologically relevant, concentrations of EPI (300 nM) are able to desensitize the ?
Localization (concentrations) of EPI in EPI
13) Confidence 0.28 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0.28 Pain Relevance 0.15
2A-AR signal is not desensitized following 24 hr treatment with modest concentrations of EPI or NE (300 nM and 1 ?
Localization (concentrations) of EPI in EPI
14) Confidence 0.28 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0.08 Pain Relevance 0.22
2-AR desensitization (p < 0.05; Fig. 4), but had no effect in the absence of EPI.


Neg (absence) Localization (absence) of EPI in EPI
15) Confidence 0.28 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.15
With near threshold (3 Hz) stimulation, the following differences were observed between groups: (1) secretion of EPI, NPY, and ENK was significantly greater in the chronic than in the acute animals; and (2) preferential secretion of NE was elicited in the acute animals.
Localization (secretion) of EPI in EPI associated with enkephalin
16) Confidence 0.17 Published 1992 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1619210 Disease Relevance 0.20 Pain Relevance 0.54
Epi, epinephrine
Localization (epinephrine) of Epi
17) Confidence 0.15 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.05
Adrenal medullary secretion (ng/min) of epinephrine (EPI), norepinephrine (NE), dopamine, neuropeptide Y (NPY), [Met]enkephalin (ENK), and encrypted [Met]enkephalin was determined at baseline and in relation to both patterns of stimulation.
Localization (secretion) of EPI in EPI associated with dopamine, neuropeptide and enkephalin
18) Confidence 0.13 Published 1992 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1619210 Disease Relevance 0.21 Pain Relevance 0.53
The epinephrine-collagen cartridge (EPI-COLL) is sensitive to aspirin and can be used for the detection of aspirin resistance [6].
Localization (cartridge) of EPI-COLL in EPI associated with aspirin
19) Confidence 0.07 Published 2005 Journal Thromb J Section Body Doc Link PMC1192820 Disease Relevance 0.06 Pain Relevance 0.21
We further described the presence of anti-CL antibodies and AECA besides anti-U1RNP antibodies in MCTD; moreover, serum levels of anti-U1RNP antibodies, anti-CL IgG and AECA were higher in the MCTD/CVD+ group compared with MCTD/CVD- patients.
Localization (presence) of anti-CL associated with cardiovascular disease and systemic sclerosis
20) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.77 Pain Relevance 0.03

General Comments

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