INT120393

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCD) mitochondrion (PRKCD) endoplasmic reticulum (PRKCD)
enzyme binding (PRKCD) cytoplasm (PRKCD) cytosol (PRKCD)
PRKCD (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 24 98.02 Very High Very High Very High
b2 receptor 6 75.00 Quite High
Pain 2 43.44 Quite Low
Inflammation 2 40.56 Quite Low
Kinase C 3 5.00 Very Low Very Low Very Low
Vanilloid receptor-like 3 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 25 97.52 Very High Very High Very High
Metastasis 5 94.12 High High
Prostate Cancer 83 89.88 High High
Disease 7 75.08 Quite High
Breast Cancer 2 55.36 Quite High
Malignant Neoplastic Disease 2 51.40 Quite High
Pressure And Volume Under Development 2 43.92 Quite Low
Pain 2 43.44 Quite Low
Increased Venous Pressure Under Development 2 43.20 Quite Low
INFLAMMATION 2 40.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of BK on proliferation, ERK1/2 phosphorylation, and c-Fos expression were abolished by GF109203X, which inhibits PKC-delta isozyme.
Negative_regulation (inhibits) of PKC-delta associated with bradykinin
1) Confidence 0.22 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0.11 Pain Relevance 0.44
Conversely, Gö6976, an inhibitor of PKC-alpha and -beta isozymes, and the 18-h treatment of cells with PMA, that led to the complete down-regulation of PKC-alpha, -beta, -epsilon, and -eta, but not of PKC-delta, did not have any effect, thereby indicating that the PKC-delta mediates the mitogenic signalling of BK.
Negative_regulation (down-regulation) of PKC-delta associated with bradykinin
2) Confidence 0.22 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0 Pain Relevance 0.42
As shown in Figure 5, Group II, the mRNAs for PYCR1, DDT, PRKCD, and CRELD2, which were DHT-stimulated in vitro (Figure 2), were decreased in the androgen-ablated as compared to the primary untreated tumors.
Negative_regulation (decreased) of PRKCD associated with cancer
3) Confidence 0.18 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.97 Pain Relevance 0

General Comments

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