INT120394

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.58
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCD) mitochondrion (PRKCD) endoplasmic reticulum (PRKCD)
enzyme binding (PRKCD) cytoplasm (PRKCD) cytosol (PRKCD)
PRKCD (Homo sapiens)
Pain Link Frequency Relevance Heat
b2 receptor 3 99.64 Very High Very High Very High
bradykinin 12 98.60 Very High Very High Very High
Kinase C 12 97.08 Very High Very High Very High
Glutamate 4 64.08 Quite High
addiction 4 48.92 Quite Low
Inflammation 1 25.00 Low Low
Pain 1 25.00 Low Low
Vanilloid receptor-like 3 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 332 99.48 Very High Very High Very High
Repression 28 86.56 High High
Cancer 100 83.68 Quite High
Metastasis 20 81.44 Quite High
Disease 28 73.52 Quite High
Apoptosis 20 55.76 Quite High
Breast Cancer 1 25.00 Low Low
INFLAMMATION 1 25.00 Low Low
Pain 1 25.00 Low Low
Pressure And Volume Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, BK has mitogenic actions in cultured human epithelial breast cells; the activation of PKC-delta through B2 receptor acts in concert with ERK and PI3K pathways to induce cell proliferation.
Positive_regulation (activation) of PKC-delta associated with b2 receptor and bradykinin
1) Confidence 0.26 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0 Pain Relevance 0.33
The three genes most strongly stimulated by DHT in C4-2B cells – DDT, CRELD2 and PRKCD – were also stimulated in LNCaP cells (Figure 2A, B, C), although the stimulation of DDT and PRKCD was more modest in LNCaP cells.
Positive_regulation (stimulated) of PRKCD
2) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.22 Pain Relevance 0
The three genes most strongly stimulated by DHT in C4-2B cells – DDT, CRELD2 and PRKCD – were also stimulated in LNCaP cells (Figure 2A, B, C), although the stimulation of DDT and PRKCD was more modest in LNCaP cells.
Positive_regulation (stimulation) of PRKCD
3) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.22 Pain Relevance 0
CRELD2, PRKCD and GSTT2 were stimulated (Figure 2B, C, D, solid lines), whereas MUC6, KIAA1217, and WBSCR28 were repressed (Figure 2ZC, ZE, ZF, solid lines).
Positive_regulation (stimulated) of PRKCD
4) Confidence 0.21 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 0.14 Pain Relevance 0
PRKCD mRNA levels were higher in DHT-treated as compared to untreated PCa cell cultures and were reduced in PCa biopsies from patients undergoing androgen ablation therapy as compared to those from untreated patients.
Positive_regulation (higher) of PRKCD mRNA associated with prostate cancer
5) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904239 Disease Relevance 1.00 Pain Relevance 0.08

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