INT120396

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCD) mitochondrion (PRKCD) endoplasmic reticulum (PRKCD)
enzyme binding (PRKCD) cytoplasm (PRKCD) cytosol (PRKCD)
PRKCD (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 24 99.98 Very High Very High Very High
b2 receptor 6 91.92 High High
Pain 2 66.68 Quite High
Inflammation 2 63.80 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 2 78.60 Quite High
Malignant Neoplastic Disease 2 74.64 Quite High
Pressure And Volume Under Development 2 67.16 Quite High
Pain 2 66.68 Quite High
Increased Venous Pressure Under Development 2 66.44 Quite High
INFLAMMATION 2 63.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracellular effects of B2 stimulation were the following: (a) the increase of free intracellular Ca(2+) concentration by a mechanism dependent upon the phospholipase C (PLC) activity; (b) the cytosol-to-membrane translocation of conventional (PKC)-alpha and -beta isozymes, novel PKC-delta, -epsilon, and -eta isozymes; (c) the phosphorylation of the extracellular-regulated kinase 1 and 2 (ERK1/2); and (d) the stimulation of the expression of c-Fos protein.
Positive_regulation (upon) of Localization (translocation) of PKC-delta
1) Confidence 0.26 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0.42 Pain Relevance 0.51
In addition, the BK induced cytosol-to-membrane translocation of PKC-delta was blocked by PI3K inhibition, suggesting that PI3K is upstream to PKC-delta.
Positive_regulation (induced) of Localization (translocation) of PKC-delta associated with bradykinin
2) Confidence 0.26 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0 Pain Relevance 0.34

General Comments

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