INT120406

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.48
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BDKRB2) plasma membrane (BDKRB2) signal transducer activity (BDKRB2)
BDKRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 39 100.00 Very High Very High Very High
b2 receptor 3 100.00 Very High Very High Very High
bradykinin 210 99.60 Very High Very High Very High
Inflammation 10 92.60 High High
agonist 30 71.44 Quite High
Pain 4 25.00 Low Low
antagonist 9 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 92.60 High High
Increased Venous Pressure Under Development 4 91.92 High High
Pathologic Processes 6 91.00 High High
Cancer 12 89.52 High High
Glioma 39 82.80 Quite High
Neuroblastoma 3 53.12 Quite High
Anaplastic Astrocytoma 12 37.44 Quite Low
Pain 4 25.00 Low Low
Breast Cancer 1 25.00 Low Low
Pressure And Volume Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B2R activation also activates PKC, phosphatase A2, phospholipase C, and phosphoinositide 3-kinase (PI3K), and stimulates production of nitric oxide [19,20].
Positive_regulation (stimulates) of Positive_regulation (activation) of B2R associated with kinase c
1) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.55 Pain Relevance 0.35
B2R activation also activates PKC, phosphatase A2, phospholipase C, and phosphoinositide 3-kinase (PI3K), and stimulates production of nitric oxide [19,20].
Positive_regulation (activates) of Positive_regulation (activation) of B2R associated with kinase c
2) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.48 Pain Relevance 0.31
Activation of B2R is preferentially coupled to G proteins of the G?
Positive_regulation (coupled) of Positive_regulation (Activation) of B2R
3) Confidence 0.27 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.46 Pain Relevance 0.29
In conclusion, BK has mitogenic actions in cultured human epithelial breast cells; the activation of PKC-delta through B2 receptor acts in concert with ERK and PI3K pathways to induce cell proliferation.
Positive_regulation (induce) of Positive_regulation (activation) of B2 receptor associated with b2 receptor and bradykinin
4) Confidence 0.26 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0 Pain Relevance 0.33

General Comments

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