INT120432

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 22
Total Number 29
Disease Relevance 9.65
Pain Relevance 12.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 3
skin 3
DRG 3
epithelial cell 1
nociceptor 1
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 270 100.00 Very High Very High Very High
Inflammation 251 100.00 Very High Very High Very High
TRP channel 124 100.00 Very High Very High Very High
Root ganglion neuron 48 100.00 Very High Very High Very High
Opioid 90 99.98 Very High Very High Very High
Cold hyperalgesia 8 99.82 Very High Very High Very High
Pain 150 99.68 Very High Very High Very High
nociceptor 99 99.64 Very High Very High Very High
qutenza 162 99.52 Very High Very High Very High
Dorsal horn neuron 32 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 262 100.00 Very High Very High Very High
Ganglion Cysts 119 100.00 Very High Very High Very High
Nociception 81 100.00 Very High Very High Very High
Hyperalgesia 28 99.82 Very High Very High Very High
Neuropathic Pain 58 99.56 Very High Very High Very High
Hypersensitivity 19 98.80 Very High Very High Very High
Asthma 1 98.56 Very High Very High Very High
Stress 5 97.84 Very High Very High Very High
Osteoarthritis 84 96.84 Very High Very High Very High
Pain 161 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that TRPA1 function is modulated under pathological conditions.
Regulation (modulated) of TRPA1
1) Confidence 0.61 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.62 Pain Relevance 0.30
TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine.
Regulation (modulated) of TRPA1
2) Confidence 0.61 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17218316 Disease Relevance 0 Pain Relevance 0.09
In contrast to its effect on TRPA1, URB597 inhibited TRPM8 and had no effects on TRPV1 or TRPV4.
Regulation (effect) of TRPA1
3) Confidence 0.60 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17314320 Disease Relevance 0.10 Pain Relevance 0.17
[Activation and regulation of nociceptive transient receptor potential (TRP) channels, TRPV1 and TRPA1].
Regulation (regulation) of TRPA1 associated with nociception and pain
4) Confidence 0.51 Published 2010 Journal Yakugaku Zasshi Section Title Doc Link 20190512 Disease Relevance 1.04 Pain Relevance 0.63
Effects of TRPA1 agonists mustard oil and cinnamaldehyde on lumbar spinal wide-dynamic range neuronal responses to innocuous and noxious cutaneous stimuli in rats.
Regulation (Effects) of TRPA1 in neuronal associated with agonist
5) Confidence 0.45 Published 2008 Journal J. Neurophysiol. Section Title Doc Link 17942619 Disease Relevance 0.09 Pain Relevance 0.29
We examined the influence of TRPA1 on the epithelial restitution using a rat gastric epithelial cell line RGM1 monolayer.
Spec (examined) Regulation (influence) of TRPA1 in epithelial cell
6) Confidence 0.45 Published 2007 Journal Inflammopharmacology Section Abstract Doc Link 17943255 Disease Relevance 0.31 Pain Relevance 0
These results rule out any role for TRPA1 and TRPV1 channels in mechanotransduction processes of slowly adapting type II mechanoreceptors.
Regulation (role) of TRPA1 in mechanoreceptors associated with mechanotransduction
7) Confidence 0.45 Published 2009 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 20021572 Disease Relevance 0.07 Pain Relevance 0.38
In the present study, we investigated the effect of these molecules on TRPA1 gating.
Spec (investigated) Regulation (effect) of TRPA1
8) Confidence 0.45 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17218316 Disease Relevance 0 Pain Relevance 0.08
On the other hand, the positively charged drug chlorpromazine modulates activated TRPA1 currents in a voltage-dependent way.
Regulation (modulates) of TRPA1
9) Confidence 0.45 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17218316 Disease Relevance 0 Pain Relevance 0.06
In the present study, we precisely examined the incidence of cold hyperalgesia and the changes of TRPA1 and TRPM8 expression in the L4 and L5 DRG following L5 spinal nerve ligation (SNL), because it is likely that the activation of two distinct populations of TRPA1- and TRPM8-expressing small neurons underlie the sensation of cold.
Regulation (changes) of TRPA1 in DRG associated with dorsal root ganglion, hyperalgesia, cold hyperalgesia and eae
10) Confidence 0.44 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16546170 Disease Relevance 1.15 Pain Relevance 0.82
The functional properties of the population of TRPA1-expressing afferents have yet to be defined.
Regulation (population) of TRPA1-expressing
11) Confidence 0.44 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.66 Pain Relevance 0.68
To determine whether TRPA1-positive afferent properties are affected in acute inflammation, specifically in relation to mechanical stimuli, the mechanical thresholds of TRPA1-positive and TRPA1-negative afferents from both inflamed and normal skin were obtained.
Spec (whether) Regulation (affected) of TRPA1 in skin associated with inflammation
12) Confidence 0.44 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.10 Pain Relevance 0.22
To determine whether TRPA1-positive afferent properties are affected in acute inflammation, specifically in relation to mechanical stimuli, the mechanical thresholds of TRPA1-positive and TRPA1-negative afferents from both inflamed and normal skin were obtained.
Spec (whether) Regulation (affected) of TRPA1 in skin associated with inflammation
13) Confidence 0.44 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.10 Pain Relevance 0.24
This approach has been used previously to differentiate TRPV1, TRPM8 and TRPA1 sensitive inputs to dorsal horn neurons in intact spinal cord slices [25-32].
Regulation (differentiate) of TRPA1 in neurons associated with dorsal horn neuron and spinal cord
14) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987996 Disease Relevance 0.17 Pain Relevance 0.65
Here we have characterized the pharmacological effects of citral on several TRP channels known to be present in dorsal root ganglion neurons, including TRPV1–4, TRPM8, and TRPA1.
Regulation (effects) of TRPA1 in neurons associated with ganglion cysts, trp channel and root ganglion neuron
15) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.33 Pain Relevance 0.29
Of the bladder-innervating DRG neurons identified by retrograde labeling, 50.8% showed TRPA1 immunoreactivity.
Regulation (immunoreactivity) of TRPA1 in DRG
16) Confidence 0.27 Published 2007 Journal Urology Section Body Doc Link 17991581 Disease Relevance 0.07 Pain Relevance 0
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

Background

Regulation (modulation) of TRPA1 in neurons associated with osteoarthritis
17) Confidence 0.27 Published 2010 Journal Mol Pain Section Title Doc Link PMC2841076 Disease Relevance 0.17 Pain Relevance 0.21
TRPA1 ablated mice (TRPA1-/-) were less sensitive to low-intensity mechanical stimuli compared to wild-type mice, and responses to high-intensity mechanical stimulation were appreciably impaired [13].
Regulation (sensitive) of TRPA1
18) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2841076 Disease Relevance 0.31 Pain Relevance 0.39
Altering the temperature of the receptive field did not modulate TRPA1 agonist evoked-activity in cutaneous primary afferents, in either normal or inflamed skin.
Neg (not) Regulation (modulate) of TRPA1 in skin associated with agonist
19) Confidence 0.27 Published 2010 Journal Neuroscience Section Abstract Doc Link PMC2860241 Disease Relevance 0.10 Pain Relevance 0.87
TRP channel block of cold and TRPA1 agonist responses in cutaneous primary afferents
Regulation (responses) of TRPA1 associated with trp channel and agonist
20) Confidence 0.27 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.18 Pain Relevance 0.46

General Comments

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