INT120433

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 11
Total Number 19
Disease Relevance 8.56
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
reticulum 3
sensory neurons 1
spinal nerve 1
plasma 1
MCF-7 1
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 15 100.00 Very High Very High Very High
qutenza 34 99.52 Very High Very High Very High
agonist 11 99.40 Very High Very High Very High
nociceptor 7 97.76 Very High Very High Very High
Pain 74 95.96 Very High Very High Very High
Lasting pain 2 95.56 Very High Very High Very High
member 8 15 95.20 Very High Very High Very High
Spinal cord 44 94.40 High High
antagonist 6 90.64 High High
Hyperalgesia 9 86.24 High High
Disease Link Frequency Relevance Heat
Breast Cancer 175 99.92 Very High Very High Very High
Heart Disease 3 99.48 Very High Very High Very High
Reprotox - General 1 54 99.32 Very High Very High Very High
Adenocarcinoma 63 99.04 Very High Very High Very High
Diabetes Mellitus 100 96.88 Very High Very High Very High
Cancer 112 96.72 Very High Very High Very High
Neuropathic Pain 60 96.48 Very High Very High Very High
Neuroma 16 95.64 Very High Very High Very High
Pain 46 95.56 Very High Very High Very High
Syndrome 1 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to determine whether the human TRPM8 was regulated by estrogens, we cultured MCF-7 cells in starved medium (0 FCS) or steroid-free medium (5% dextran-coated charcoal-treated FCS (DCCFCS).
Spec (whether) Regulation (regulated) of TRPM8 in MCF-7
1) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.07 Pain Relevance 0
regulation of TRPM8 in a physiological context, we studied the correlation between the over-expression of TRPM8 and ER?
Regulation (regulation) of TRPM8
2) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.53 Pain Relevance 0.03
We also show that TRPM8 is modulated by ethanol but unlike TRPV1 is insensitive to extracellular acidification.
Regulation (modulated) of TRPM8
3) Confidence 0.61 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15911692 Disease Relevance 0 Pain Relevance 0.17
In contrast, PMTRPM8 channels are regulated by the differentiation and androgen receptor status [27,29].
Regulation (regulated) of TRPM8
4) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.44 Pain Relevance 0
The androgen-regulated trpm8 expression mechanisms are important in understanding the progression of prostate cancer to androgen-independence.
Regulation (androgen-regulated) of trpm8 associated with reprotox - general 1
5) Confidence 0.45 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.25 Pain Relevance 0.06
Prevarskaya's group has demonstrated that the ERTRPM8 is a truncated TRPM8 isoform which acts as an endoplasmic reticulum calcium releasing channel and which is not regulated by differentiation status [27,29].
Neg (not) Regulation (regulated) of TRPM8 in reticulum
6) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.48 Pain Relevance 0
We report evidence from immunofluorescence experiments that in the androgen-responsive LNCaP cell line, the TRPM8 protein is expressed in the endoplasmic reticulum and plasma membrane, acts as a Ca(2+)-permeable channel (assessed using Fura-2 to measure increases in the cytoplasmic Ca(2+) concentration) in each of these membranes, and is regulated by androgen.
Regulation (regulated) of TRPM8 protein in plasma
7) Confidence 0.45 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548706 Disease Relevance 0.26 Pain Relevance 0.04
Prevarskaya's group has demonstrated that the ERTRPM8 is a truncated TRPM8 isoform which acts as an endoplasmic reticulum calcium releasing channel and which is not regulated by differentiation status [27,29].
Neg (not) Regulation (regulated) of TRPM8 in reticulum
8) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.48 Pain Relevance 0
Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate.
Regulation (control) of TRPM8
9) Confidence 0.27 Published 2005 Journal J. Neurosci. Section Title Doc Link 15716403 Disease Relevance 0 Pain Relevance 0
The present study aimed at investigating the expression, function and potential regulation of TRPM8 channels by ER alpha (estrogen receptor alpha) in breast cancer.


Spec (investigating) Regulation (regulation) of TRPM8 associated with breast cancer
10) Confidence 0.27 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2887400 Disease Relevance 0.33 Pain Relevance 0.16
Regulation of TRPM8 by androgens in prostate cancer cells was suggested by Tsavaler et al [17] and confirmed in LNCaP cell line [20,22].
Regulation (Regulation) of TRPM8 associated with reprotox - general 1
11) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.89 Pain Relevance 0
The pathological role of transient receptor potential channels in heart disease.
Regulation (role) of transient receptor potential in heart associated with trp channel and heart disease
12) Confidence 0.22 Published 2009 Journal Circ. J. Section Title Doc Link 19202304 Disease Relevance 0.76 Pain Relevance 0.21
The aim of the present study was to investigate the distribution of the vanilloid receptors TRPV1, TRPV3, TRPV4, and TRPM8 in normal and injured human peripheral nerves and spinal nerve roots and in normal and neuropathic (painful neuroma and diabetes) skin and spinal cord,

Methods

Spec (investigate) Regulation (distribution) of TRPM8 in peripheral nerves associated with pain, diabetes mellitus, neuropathic pain, neuroma and spinal cord
13) Confidence 0.22 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.95 Pain Relevance 0.59
Two further, temperature sensitive, ion channels TRPM8 and TRPA1 are localised in sensory neurons and are sensitive to cool/cold temperatures < 25–28°C for TRPM8 and < 17°C for TRPA1 [3,5,9].
Regulation (sensitive) of TRPM8 in sensory neurons
14) Confidence 0.22 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.86 Pain Relevance 0.64
TRPM8 immunoreactivity was not detected in keratinocytes.
Regulation (immunoreactivity) of TRPM8 in keratinocytes
15) Confidence 0.22 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.52 Pain Relevance 0.03
Differential behavioral effect of the TRPM8/TRPA1 channel agonist icilin (AG-3-5).
Regulation (effect) of TRPM8 associated with qutenza and agonist
16) Confidence 0.16 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17765220 Disease Relevance 0 Pain Relevance 0.40
We report evidence from immunofluorescence experiments that in the androgen-responsive LNCaP cell line, the TRPM8 protein is expressed in the endoplasmic reticulum and plasma membrane, acts as a Ca(2+)-permeable channel (assessed using Fura-2 to measure increases in the cytoplasmic Ca(2+) concentration) in each of these membranes, and is regulated by androgen.
Regulation (regulated) of TRPM8 protein in reticulum
17) Confidence 0.15 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548706 Disease Relevance 0.26 Pain Relevance 0.04
The aim of the present study was to investigate the distribution of the vanilloid receptors TRPV1, TRPV3, TRPV4, and TRPM8 in normal and injured human peripheral nerves and spinal nerve roots and in normal and neuropathic (painful neuroma and diabetes) skin and spinal cord,

Methods

Spec (investigate) Regulation (distribution) of TRPM8 in spinal nerve associated with pain, diabetes mellitus, neuropathic pain, neuroma and spinal cord
18) Confidence 0.07 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.95 Pain Relevance 0.59
TRP channels of the vanilloid family (TRPV1, TRPV2, TRPV3, TRPV4) are excited by heat stimuli whereas TRPM8 and ANKTM1 are cold responsive.
Regulation (responsive) of TRPM8 associated with trp channel
19) Confidence 0.06 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15283452 Disease Relevance 0.52 Pain Relevance 0.79

General Comments

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