INT120447

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.74
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
pancreas 4
T cell 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 5 99.02 Very High Very High Very High
antagonist 15 98.06 Very High Very High Very High
agonist 66 96.24 Very High Very High Very High
Multiple sclerosis 44 95.48 Very High Very High Very High
Cannabinoid receptor 5 93.68 High High
antinociception 5 87.80 High High
glial activation 1 52.92 Quite High
tolerance 30 50.00 Quite Low
cytokine 21 39.68 Quite Low
Central nervous system 43 15.96 Low Low
Disease Link Frequency Relevance Heat
Hyperglycemia 8 98.04 Very High Very High Very High
Multiple Sclerosis 112 95.48 Very High Very High Very High
Disease 31 94.16 High High
Apoptosis 6 92.88 High High
Hypothermia 5 88.32 High High
Catalepsy 5 86.64 High High
Diabetes Mellitus 31 79.88 Quite High
Autoimmune Disease 40 64.48 Quite High
Disorder Of Lipid Metabolism 1 60.84 Quite High
Death 5 34.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, pretreatment with a peroxisome proliferator-activated receptor gamma (PPARgamma)-specific antagonist, T0070907 [2-chloro-5-nitro-N-4-pyridinyl-benzamide], partially antagonized anandamide-mediated suppression of IL-2 secretion.
Negative_regulation (suppression) of Localization (secretion) of IL-2 associated with antagonist
1) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.05
Moreover, NS398 [N-[2-(cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide], a cyclooxygenase-2-specific inhibitor, also attenuated the inhibitory effects of anandamide and arachidonic acid upon interleukin-2 secretion.
Negative_regulation (attenuated) of Localization (secretion) of interleukin-2
2) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.07
Collectively, the aforementioned studies suggest that inhibition of interleukin-2 secretion by anandamide is independent of CB1/CB2 and the AMT/FAAH system.
Negative_regulation (inhibition) of Localization (secretion) of interleukin-2
3) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.05
A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes.
Negative_regulation (inhibition) of Localization (secretion) of interleukin-2 associated with cox2
4) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15284281 Disease Relevance 0.17 Pain Relevance 0.22
Interestingly, arachidonic acid caused a concentration-dependent inhibition of interleukin-2 secretion (IC(50) = 10.3 microM), which was similar to that of structurally related anandamide (IC(50) = 11.4 microM).
Negative_regulation (inhibition) of Localization (secretion) of interleukin-2
5) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0.12 Pain Relevance 0.15
In agreement with these results, we found that IL-2 neutralization blocked the migration of donor CD8+ T cells into the pancreas in 50% of mice analyzed at day 13 post transfer and reduced the number of infiltrating cells in the remaining mice (Fig. 3C).
Negative_regulation (reduced) of Localization (neutralization) of IL-2 in pancreas
6) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.59 Pain Relevance 0
In agreement with these results, we found that IL-2 neutralization blocked the migration of donor CD8+ T cells into the pancreas in 50% of mice analyzed at day 13 post transfer and reduced the number of infiltrating cells in the remaining mice (Fig. 3C).
Negative_regulation (blocked) of Localization (neutralization) of IL-2 in pancreas
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.54 Pain Relevance 0
Since vitamin D3 inhibits the secretion of IL-2, which is essential for the generation of Treg cells [37], [38], we first measured IL-2 levels in the culture supernatant after stimulation with vitamin D3.
Negative_regulation (inhibits) of Localization (secretion) of IL-2
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0 Pain Relevance 0
inhibited T cell secretion of IL-2 and altered T cell proliferation [46].
Negative_regulation (inhibited) of Localization (secretion) of IL-2 in T cell
9) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.31 Pain Relevance 0.32

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